QUANTITATIVE ULTRASTRUCTURAL STUDIES OF AXON SCHWANN CELL ABNORMALITY IN SPINAL NERVE ROOTS FROM DYSTROPHIC MICE
QUANTITATIVE ULTRASTRUCTURAL STUDIES OF AXON SCHWANN CELL ABNORMALITY IN SPINAL NERVE ROOTS FROM DYSTROPHIC MICE
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DOI：
10.1097/00005072-197511000-00006
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发表时间：
1975-01-01
影响因子：
3.2
通讯作者：
AGUAYO, AJ
中科院分区：
文献类型：
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作者：
BRAY, GM;AGUAYO, AJ
应用超微结构定量技术对正常和营养不良小鼠腰骶神经根和腓肠肌内侧肌（NMG）神经进行了观察。结果表明，虽然在这个水平的许多轴突是完全没有雪旺细胞，轴突总数是大致正常的。部分轴突被雪旺细胞包围，但髓鞘异常薄。此外，在营养不良小鼠的背根中观察到类似少突胶质细胞的细胞。与此相反，雪旺细胞和髓鞘是正常的，在更外围位于NMG和这些神经的再生反应挤压injury是没有显着不同的控制nerve.Thus，营养不良小鼠的主要异常的神经形态是一个局部缺乏雪旺细胞。这种缺陷似乎并没有影响轴突的生长或这些轴突再生的能力时，粉碎远端。
Lumbo-sacral spinal roots and the nerve to the medial gastrocnemius muscle (NMG) from normal and dystrophic mice were examined by quantitative ultrastructural techniques. It was demonstrated that, although many axons at this level were totally devoid of Schwann cells, total axonal numbers were approximately normal. Some axons in these roots were surrounded by Schwann cells but their myelin sheaths were abnormally thin. In addition, cells resembling oligodendrocytes were observed in the dorsal roots of the dystrophic mice. In contrast, Schwann cells and myelin sheaths were normal in the more peripherally situated NMG and the regenerative response of these nerves to crush injury was not significantly different from that of control nerves.Thus, the main abnormality of neural morphology in dystrophic mice is a localized absence of Schwann cells. Such a deficiency does not appear to have influenced axonal growth or the capacity of these axons to regenerate when crushed distally.