The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components
The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components
复制标题
细胞色素 P-450 催化正辛烷羟基化成主要成分和次要成分的分子内同位素效应的分离
DOI：
10.1021/ja00241a040
复制
发表时间：
1987
影响因子：
15
通讯作者：
W. Trager
中科院分区：
文献类型：
--
作者：
Jefferey P. Jones;W. Trager
The intramolecular isotope effect for the cytochrome P-450b omega-hydroxylation of (1,1,1-/sup 2/H/sub 3/)-n-octane was separated into its primary and secondary components by the method of Hanzlik. The primary isotope effect was found to lie between 7.3 and 7.9 while the secondary isotope effect was found to lie between 1.09 and 1.14. These data are consistent with a highly symmetrical transition state with 15% of the observed isotope effect being due to secondary isotope effects. Although the system was found to depart from the rule of the geometric mean, the phenomenon could not be attributed to tunneling.
