Cytokines regulating hematopoietic stem cell function.
Cytokines regulating hematopoietic stem cell function.
复制标题
DOI：
10.1097/moh.0b013e3283007db5
复制
发表时间：
2008-07
影响因子：
3.2
通讯作者：
Lodish HF
中科院分区：
文献类型：
--
作者：
Zhang CC;Lodish HF
造血干细胞的多种命运的调节-包括静止、自我更新、分化、凋亡和从小生境的动员-需要与这些细胞上的受体结合的几种细胞因子和其他激素的协同作用。在这篇综述中，我们讨论了新的造血干细胞支持细胞因子的识别和机制，它们控制造血干细胞的命运决定的最新进展。最近通过许多实验方法确定了几种刺激造血干细胞体外扩增的外在因素，包括正向遗传筛选和支持性基质细胞的转录谱分析。近年来造血干细胞中多种细胞因子信号通路被激活或抑制的实验揭示了体内和体外造血干细胞中信号转导和细胞命运选择的复杂性。转基因小鼠的研究和造血干细胞体外培养系统的改进将是阐明调节造血干细胞功能的细胞因子功能的有力工具。这些将进一步揭示外源性因素调节造血干细胞信号转导和细胞命运决定机制的复杂性。
Regulation of the multiple fates of hematopoietic stem cells – including quiescence, self-renewal, differentiation, apoptosis, and mobilization from the niche – requires the cooperative actions of several cytokines and other hormones that bind to receptors on these cells. In this review we discuss recent advances in the identification of novel hematopoietic stem cell supportive cytokines and the mechanisms by which they control hematopoietic stem cell fate decisions. Several extrinsic factors that stimulate ex-vivo expansion of hematopoietic stem cells were recently identified by a number of experimental approaches, including forward genetic screening and transcriptional profiling of supportive stromal cells. Recent experiments in which multiple cytokine signaling pathways are activated or suppressed in hematopoietic stem cells reveal the complexity of signal transduction and cell-fate choice in hematopoietic stem cells in vivo and in vitro. The study of genetically modified mice and improvements in the in-vitro hematopoietic stem cell culture system will be powerful tools to elucidate the functions of cytokines that regulate hematopoietic stem cell function. These will further reveal the complex nature of the mechanisms by which extrinsic factors regulate signal transduction and cell-fate decisions of hematopoietic stem cells.