Electrical conductivity images of biological tissue phantoms in MREIT
Electrical conductivity images of biological tissue phantoms in MREIT
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DOI：
10.1088/0967-3334/26/2/026
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发表时间：
2005-04-01
影响因子：
3.2
通讯作者：
Seo, JK
中科院分区：
文献类型：
--
作者：
Oh, SH;Lee, BI;Seo, JK
我们提出了两个生物组织模型的横截面电导率图像。每个直径和高度均为140 mm的圆柱形体模在作为背景介质的导电琼脂明胶内含有生物组织块，例如牛舌和肝脏、猪肌肉和鸡胸。我们将四个凹陷的电极连接在体模的两侧，电极之间的间距相等。采用基于3.0 T MRI扫描仪的磁共振电阻抗断层成像（MREIT）系统，分别向体模沿着两个不同方向注入480或120 mA/ms的电流脉冲，测量了体模中感应磁通密度B =（B-x，B-y，B-z）的z分量B-z。使用谐波B-z算法，我们从测量的B-z数据重建横截面电导率图像。重建图像清楚地区分不同的组织在其形状和导电率值。在本文中，我们实验证明了MREIT技术的可行性，在不同的生物软组织的电导率图像具有高的空间分辨率和准确性时，我们使用了足够量的注入电流。
We present cross-sectional conductivity images of two biological tissue phantoms. Each of the cylindrical phantoms with both diameter and height of 140 mm contained chunks of biological tissues such as bovine tongue and liver, porcine muscle and chicken breast within a conductive agar gelatin as the background medium. We attached four recessed electrodes on the sides of the phantom with equal spacing among them. Injecting current pulses of 480 or 120 mA ms into the phantom along two different directions, we measured the z-component B-z of the induced magnetic flux density B = (B-x, B-y, B-z) with a magnetic resonance electrical impedance tomography (MREIT) system based on a 3.0 T MRI scanner. Using the harmonic B-z algorithm, we reconstructed cross-sectional conductivity images from the measured B-z data. Reconstructed images clearly distinguish different tissues in terms of both their shapes and conductivity values. In this paper, we experimentally demonstrate the feasibility of the MREIT technique in producing conductivity images of different biological soft tissues with a high spatial resolution and accuracy when we use a sufficient amount of the injection current.