Effects of electric field stimulation timing on calcium dynamics of cultured cardiomyocytes
Effects of electric field stimulation timing on calcium dynamics of cultured cardiomyocytes
复制标题
电场刺激时机对培养心肌细胞钙动态的影响
DOI：
10.1002/tee.21927
复制
发表时间：
2013
影响因子：
1
通讯作者：
Kunihiko Mabuchi
中科院分区：
文献类型：
--
作者：
Leo Miyashita;Yuzo Takayama;Tatsuya Haga;Takafumi Suzuki;Kunihiko Mabuchi
为了提出有效的低强度心肌细胞刺激方法，对培养的心肌细胞施加电场刺激，并通过钙离子成像记录和分析其反应。因此，我们证实了钙瞬变峰值后的电场刺激（晚期刺激）暂时延长了钙瞬变周期第三个最大值的全宽。通过优化施加时间，电场刺激将是控制心肌细胞动力学的更有效方法。© 2013日本电气工程师协会。出版社：John Wiley & Sons，Inc.
In this article, in order to propose the effective and low‐intensity stimulation method for cardiomyocyte, electric field stimulation was applied to cultured cardiomyocytes, and its responses were recorded and analyzed in term of applied timing by calcium imaging. As a result, we confirmed that electric field stimulation after peak of calcium transients (late‐phase stimulation) lengthened the full width at third maximum of calcium transient cycles temporarily. By optimizing the applied timing, electric field stimulation would be more effective method for controlling cardiomyocyte dynamics. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
影响因子：
3.4
作者：
Cysyk, Joshua;Tung, Leslie
通讯作者：
Tung, Leslie
影响因子：
5.2
作者：
L. Tung;O. Tovar;M. Neunlist;Sandeep K. Jain;R. O'Neill
通讯作者：
R. O'Neill