Hunger selectively modulates corticolimbic activation to food stimuli in humans
Hunger selectively modulates corticolimbic activation to food stimuli in humans
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DOI：
10.1037//0735-7044.115.2.493
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发表时间：
2001-04-01
影响因子：
1.9
通讯作者：
Mesulam, MM
中科院分区：
文献类型：
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作者：
LaBar, KS;Gitelman, DR;Mesulam, MM
功能磁共振成像(FMRI)被用来确定人类杏仁核和相关皮质边缘结构对食物的视觉反应是否会因饥饿状态的变化而选择性地改变。参与者在交替饥饿和饱食的条件下进行功能磁共振成像时，观看了与动机相关的(食物)和动机无关的(工具)物体的图像。当参与者处于饥饿状态时，与食物相关的视觉刺激在杏仁核、海马旁回和前梭形回中引起更大的反应。这些大脑结构的状态依赖激活并不适用于动机无关的物体。这些结果支持这样的假设，即杏仁核和相关的颞下区参与了主观感觉间状态与相关感觉线索的整合，这些线索沿着腹侧视觉流进行处理。
Functional magnetic resonance imaging (fMRI) was used to determine whether visual responses to food in the human amygdala and related corticolimbic structures would be selectively altered by changes in states of hunger. Participants viewed images of motivationally relevant (food) and motivationally irrelevant (tool) objects while undergoing fMRI in alternately hungry and satiated conditions. Food-related visual stimuli elicited greater responses in the amygdala, parahippocampal gyrus, and anterior fusiform gyrus when participants were in a hungry state relative to a satiated state. The state-dependent activation of these brain structures did not generalize to the motivationally irrelevant objects. These results support the hypothesis that the amygdala and associated inferotemporal regions are involved in the integration of subjective interoceptive states with relevant sensory cues processed along the ventral visual stream.