Cajal's contributions to glia research.
Cajal's contributions to glia research.
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DOI：
10.1016/j.tins.2007.06.008
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发表时间：
2007-09-01
影响因子：
15.9
通讯作者：
Freire, Miguel
中科院分区：
文献类型：
--
作者：
Garcia-Marin, Virginia;Garcia-Lopez, Pablo;Freire, Miguel
1906年，圣地亚哥·拉蒙·卡哈尔被授予诺贝尔生理学或医学奖，以表彰他在神经元结构及其连接方面的工作。鲜为人知的是，他对神经胶质细胞也有浓厚的兴趣，并为其研究开发了特定的染色方法。除了描述它们的形态外，他还推测了神经胶质在睡眠和清醒中，甚至在大脑的执行功能（如注意力）中的作用。本文主要介绍Cajal在神经胶质细胞方面的组织学研究；这项研究包括星形胶质细胞、少突胶质细胞、小胶质细胞和放射状胶质细胞的原始图纸，以及他的科学著作。我们的目标是证明，在神经胶质和神经元方面，卡哈尔远远领先于他的时代。
In 1906, Santiago Ramon y Cajal was awarded the Nobel Prize in Physiology or Medicine in recognition of his work on the structure of neurons and their connections. What is less well known is that he also had a keen interest in glia and developed specific staining methods for their study. In addition to describing their morphology, he speculated on a role for glia in sleep and wakefulness and even in executive brain functions such as attention. In this article, we focus on Cajal's histological research into glial cells; this research includes original drawings of astrocytes, oligodendrocytes, microglia and radial glia, as well as his scientific writings. We aim to show that, concerning glia as well as neurons, Cajal was far ahead of his time.