Interactions between murine alveolar macrophages and Mycoplasma pulmonis in vitro.
Interactions between murine alveolar macrophages and Mycoplasma pulmonis in vitro.
复制标题
体外小鼠肺泡巨噬细胞与肺支原体之间的相互作用。
DOI：
10.1128/iai.29.2.590-599.1980
复制
发表时间：
1980
影响因子：
3.1
通讯作者：
Cassell,GH
中科院分区：
文献类型：
--
作者：
Davis,JK;Delozier,KM;Asa,DK;Minion,FC;Cassell,GH
与同系成纤维细胞相比，从Fischer 344大鼠收集的肺泡巨噬细胞显示出显著降低细胞相关肺支原体生长速率的能力，即使在不存在特异性动支原体抗体的情况下。然而，当暴露于醋酸铊（一种细胞毒性重金属）时，巨噬细胞支持支原体的生长几乎和未处理的成纤维细胞一样好。这表明在未处理的巨噬细胞中存在活性抗支原体过程。相反，小鼠肺泡巨噬细胞不能发挥抗支原体作用，除非兔抗M。存在肺结核抗体。巧合的是，小鼠抗M.肺抗体不促进这种作用。
In comparison to syngeneic fibroblasts, alveolar macrophages collected from Fischer 344 rats demonstrated a significant ability to decrease the growth rate of cell-associated Mycoplasma pulmonis, even in the absence of specific actimycoplasmal antibodies. However, when exposed to thallium acetate (a cytotoxic heavy metal), macrophages supported growth of mycoplasmas almost as well as did untreated fibroblasts. This suggests an active antimycoplasmal process operative in untreated macrophages. In contrast, mouse alveolar macrophages were not capable of exerting an antimycoplasmal effect unless rabbit anti-M. pulmonis antibodies were present. Paradoxically, mouse anti-M. pulmonis antibodies did not promote this effect.