Hypoxia-Inducible Factor (HIF)/Vascular Endothelial Growth Factor (VEGF) Signaling in the Retina
Hypoxia-Inducible Factor (HIF)/Vascular Endothelial Growth Factor (VEGF) Signaling in the Retina
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DOI：
10.1007/978-1-4614-3209-8_35
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发表时间：
2014-01-01
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影响因子：
--
通讯作者：
Friedlander, Martin
中科院分区：
文献类型：
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作者：
Kurihara, Toshihide;Westenskow, Peter D.;Friedlander, Martin
二十年来，人们越来越清楚地认识到血管内皮生长因子（VEGF）在年龄相关性黄斑变性（AMD）和糖尿病视网膜病变（DR）等视网膜疾病的发病机制中发挥着重要作用。基于这些观察结果，抗 VEGF 疗法正在开发中并被批准用于临床治疗新生血管性眼病。缺氧诱导因子 (HIF) 是在缺氧条件下稳定和激活的转录因子，可诱导细胞在缺氧条件下生存所需的基因产物（包括 VEGF）的表达。在这里，我们讨论我们实验室和其他实验室的最新发现，这些发现定义了 HIF-VEGF 轴在视网膜中的作用。
Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.