FOCAL GASTRIC-MUCOSAL BLOOD-FLOW IN ASPIRIN-INDUCED ULCERATION
FOCAL GASTRIC-MUCOSAL BLOOD-FLOW IN ASPIRIN-INDUCED ULCERATION
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DOI：
10.1097/00000658-198704000-00010
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发表时间：
1987-04-01
影响因子：
9
通讯作者：
KOO, J
中科院分区：
文献类型：
--
作者：
GANA, TJ;HUHLEWYCH, R;KOO, J
在犬胃体分室模型上，用氢气清除法研究阿司匹林损伤时胃粘膜局部血流的变化。在粘膜暴露于局部阿司匹林之前1.5小时、期间（20 mM阿司匹林溶于150 mM HCl中1小时）和之后2小时，每15分钟在溃疡和非溃疡区域同时进行测量。暴露于阿司匹林后30分钟，溃疡区域的血流显著减少（p < 0.001），与随后出现出血灶和溃疡的局部粘膜苍白一致。随后未恢复至基础血流值。在暴露于阿司匹林后90分钟，流向非溃疡区域的血流量显著减少，但不如溃疡区域严重（p < 0.05）。随后恢复至基础水平。有人提出阿司匹林可引起不同程度的局部粘膜血流减少，血流减少到“临界值”以下的粘膜区域会出现严重损伤。
Focal gastric mucosal blood flow was studied during aspirin injury by hydrogen gas clearance in a chambered segment model of canine gastric corpus. Measurements were made simultaneously every 15 minutes at ulcerated and nonulcerated areas 1.5 hours before, during (20 mM of aspirin in 150 mM of HCl for 1 hour), and 2 hours after exposure of the mucosa to topical aspirin. There was a highly significant decrease (p < 0.001) in flow at the ulcerated areas 30 minutes after exposure to aspirin, coinciding with the appearance of focal mucosal pallor followed by subsequent hemorrhagic foci and ulceration. This was not followed by recovery to basal flow values. Blood flow to the nonulcerated areas was significantly but less severely reduced than in the ulcerated areas (p < 0.05) 90 minutes after exposure to aspirin. This was followed by recovery to basal levels. It is proposed that aspirin induces reduction of focal mucosal blood flow of varying degrees and theat mucosal areas with flow reduced to below a "critical value" develop gross damage.