Distinct hippocampal functional networks revealed by tractography-based parcellation
Distinct hippocampal functional networks revealed by tractography-based parcellation
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DOI：
10.1007/s00429-015-1084-x
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发表时间：
2016-07-01
影响因子：
3.1
通讯作者：
McAndrews, Mary Pat
中科院分区：
文献类型：
--
作者：
Adnan, Areeba;Barnett, Alexander;McAndrews, Mary Pat
最近的研究表明，前海马和后海马形成两个不同的功能神经网络的一部分。在这里，我们调查的结构基础，这种功能连接的差异，使用扩散加权成像为基础的分割。使用这种技术，我们证实了海马可以被包裹成不同的前段和后段。这些结构上定义的节段确实表现出不同的静息状态功能连接模式，其中前段与颞叶和眶额皮质的连接性更强，而后段与内侧和外侧顶叶皮质的连接性更强。此外，我们发现，后海马连接到记忆处理区域，包括背外侧前额叶皮层，海马旁，颞下回和梭状回和楔前叶，预测个体间的关系记忆表现。这些研究结果为整合结构和功能连接理解情景记忆的大脑网络提供了重要支持。
Recent research suggests the anterior and posterior hippocampus form part of two distinct functional neural networks. Here we investigate the structural underpinnings of this functional connectivity difference using diffusion-weighted imaging-based parcellation. Using this technique, we substantiated that the hippocampus can be parcellated into distinct anterior and posterior segments. These structurally defined segments did indeed show different patterns of resting state functional connectivity, in that the anterior segment showed greater connectivity with temporal and orbitofrontal cortex, whereas the posterior segment was more highly connected to medial and lateral parietal cortex. Furthermore, we showed that the posterior hippocampal connectivity to memory processing regions, including the dorsolateral prefrontal cortex, parahippocampal, inferior temporal and fusiform gyri and the precuneus, predicted interindividual relational memory performance. These findings provide important support for the integration of structural and functional connectivity in understanding the brain networks underlying episodic memory.