Intrinsic Cerebro-Cerebellar Functional Connectivity Reveals the Function of Cerebellum VI in Reading-Related Skills
Intrinsic Cerebro-Cerebellar Functional Connectivity Reveals the Function of Cerebellum VI in Reading-Related Skills
复制标题
内在的大脑-小脑功能连接揭示了小脑 VI 在阅读相关技能中的功能
DOI：
10.3389/fpsyg.2020.00420
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发表时间：
2020-03-20
影响因子：
3.8
通讯作者：
Ding, Guosheng
中科院分区：
文献类型：
--
作者：
Ang, Chen;Zhang, Jia;Ding, Guosheng
小脑VI参与阅读的报道，在典型的发展和阅读障碍的读者。然而，小脑VI对阅读的作用仍不清楚。在这里，我们已经研究了内在的小脑-小脑功能连接与两个关键的阅读相关技能-语音意识（PA）和快速自动化命名（RAN）-与功能磁共振成像技术的相关性。具体来说，我们测试的假设，小脑可能有助于阅读语音技能或自动化技能。我们选择左侧和右侧小脑VI作为ROI，并计算了静息状态下小脑-小脑的内在功能连接。我们进一步探讨了小脑-小脑静息状态功能连接（RSFC）是否以及如何与个人的阅读相关技能（包括PA和RAN）相关。结果表明，左侧缘上回与双侧小脑VI的功能连接与RAN有关，左侧小脑VI与右侧小脑VI的功能连接与PA有关。然而，PA的效果并没有生存后，RAN回归了。对照分析进一步证实，语音意识能力和快速自动化命名能力与小脑的功能性相关，而不是小脑的局部功能性。首次探讨了小脑-小脑静息状态功能连接与特定阅读相关技能之间的关系，这加深了我们对小脑VI参与阅读方式的理解。
The engagement of the cerebellum VI in reading was reported in both typically developing and dyslexic readers. However, it is still not clear how the cerebellum VI contributes to reading. Here we have examined the correlation of intrinsic cerebro-cerebellar functional connectivity with two critical reading-related skills-phonological awareness (PA) and rapid automatized naming (RAN)-with fMRI technology. Specifically, we tested the hypothesis that the cerebellum may contribute to reading either by phonological skills or by automatizing skills. We chose the left and right cerebellum VI as ROIs, and we calculated the intrinsic cerebro-cerebellar functional connectivity during a resting state. We further explored whether and how cerebro-cerebellar resting state functional connectivity (RSFC) is associated with individuals' reading-related skills including PA and RAN. The results showed that the functional connectivity between the left supramarginal gyrus and bilateral cerebellum VI was related to RAN, and the connectivity between the left insula and right cerebellum VI was related to PA. However, the effect of PA did not survive after the RAN was regressed out. Control analyses further confirmed that it was the intrinsic cerebro-cerebellar functional connectivity rather than the local cerebellar functionality that associated with phonological awareness ability and rapid automatized naming ability. For the first time, the relationship between cerebro-cerebellar resting state functional connectivity and specific reading-related skills has been explored, and this has deepened our understanding of the way the cerebellum VI is involved in reading.