EFFECTS OF EXPERIMENTAL SALMONELLA-DUBLIN INFECTION IN CATTLE GIVEN FASCIOLA-HEPATICA 13 WEEKS PREVIOUSLY
EFFECTS OF EXPERIMENTAL SALMONELLA-DUBLIN INFECTION IN CATTLE GIVEN FASCIOLA-HEPATICA 13 WEEKS PREVIOUSLY
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DOI：
10.1016/0021-9975(78)90063-4
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发表时间：
1978-01-01
影响因子：
0.8
通讯作者：
COLLIS, KA
中科院分区：
文献类型：
--
作者：
AITKEN, MM;JONES, PW;COLLIS, KA
美国都柏林，剂量从106-109个生物体不等，静脉注射。30头幼年成年牛，其中18头在13wk前感染1000个肝片吸虫囊虫。在没有吸虫的牛身上，109个都柏林链球菌被证明是致命的，而较低的剂量只会引起一过性发热。在感染吸虫的牛中5次。107个都柏林链霉菌在4个病例中有3个是致命的，与没有吸虫的动物相比，这种和低剂量的幸存者在粪便中排泄更多的都柏林链球菌的频率更高，持续时间也更长。感染都柏林吸虫26周后的尸检显示，无吸虫感染组的组织和体液为单一感染或仅轻微感染，而感染吸虫组的组织和体液为106或5倍。仍有107个生物严重感染都柏林链球菌。肝片吸虫病增加了牛对都柏林沙门氏菌致死效应的易感性，并易于发展为携带者状态。
S. dublin, in doses ranging from 106-109 organisms, was given i.v. to 30 young adult cattle, 18 of which were infected 13 wk previously with 1000 metacercariae of F. hepatica. In fluke-free cattle 109 S. dublin proved lethal, while lower doses caused only transient pyrexia. In fluke-infected cattle 5 .times. 107 S. dublin was lethal in 3 out of 4 cases and survivors of this and lower doses excreted larger numbers of S. dublin in faeces more frequently and for a longer period than did fluke-free animals. Necropsy 26 wk after infection with S. dublin revealed the tissues and body fluids of the fluke-free groups to be unifected or only lightly infected, whereas those of the fluke-infected groups given 106 or 5 .times. 107 organisms were still heavily infected with S. dublin. Fascioliasis increased the susceptibility of cattle to the lethal effects of S. dublin and predisposed to development of the carrier state.