Circadian Rhythms: Will It Revolutionise the Management of Diseases?
Circadian Rhythms: Will It Revolutionise the Management of Diseases?
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DOI：
10.15280/jlm.2019.9.1.1
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Hart, Ashley
中科院分区：
文献类型：
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作者：
Seifalian, Amelia;Hart, Ashley
2017年诺贝尔医学奖授予迈克尔·杨（Michael Young）、迈克尔·罗斯巴什（Michael Rosbash）和杰弗里·霍尔（Jeffrey Hall），以表彰他们对控制昼夜节律（CR）的分子机制的发现。本文的目的是介绍CRs背后的机制，并讨论这可能对人类健康的影响。我们认为，在这一领域的进一步研究有可能通过了解对疾病发病机制的影响，包括心血管，精神和神经健康，以及对认知功能的影响，彻底改变医疗保健。研究表明，内源性CRs对机体具有生理和生化影响，这可能会影响药物吸收的效率，由于酶的活性改变。有强有力的数据表明，由于轮班工作，睡眠障碍或时区之间的频繁旅行，CR干扰对健康有负面影响。本文旨在总结这种影响的程度，并分析CR作为潜在的治疗靶点，以及描述推动CR疾病患者病程的病理生理学和机制。这些新发现可能会彻底改变未来提供治疗的方式，更多地关注生活方式的改变，以提供治疗和更优化的精准医学。制药公司和医疗保健人员必须考虑这些数据提供的重要信息，并使用这些信息来优化药物输送和治疗提供。CRs在医疗保健中的作用的事实不能再被忽视。
The Nobel Prize for Medicine in 2017 was awarded to Michael Young, Michael Rosbash and Jeffrey Hall for their discoveries into the molecular mechanisms controlling circadian rhythms (CR). The aims of this paper were to present the mechanisms behind the CRs and discuss the impact this could have on human health. We argued that further research in this field has the potential to revolutionise healthcare through understanding the influence on the pathogenesis of disease, including in cardiovascular, mental and neurological health, as well as influence on cognitive function. The research has shown that intrinsic CRs have physiological and biochemical influences on the body, which may affect the efficiency of drug absorption due to the altered activity of enzymes. There is strong data to suggest CR disturbances, due to either shift work, sleep disorders or frequent travel between time zones, has negative impact on health. This article aims to summarise the extent of this impact and analyse CRs as a potential therapeutic target, as well as describing the pathophysiology and mechanisms driving the course of disease among people with CR disorders. These new discoveries may revolutionise the way in which treatment is provided in the future with more focus on lifestyle changes to provide treatment and more optimal precision medicine. Pharmaceutical companies and healthcare staff must consider the significant message provided from this data and use the information to optimise drug delivery and treatment provision. The facts of CRs role in healthcare can no longer be ignored.