The role of serum apelin in retinopathy of prematurity.
The role of serum apelin in retinopathy of prematurity.
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DOI：
10.2147/opth.s127943
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Shehab MM
中科院分区：
文献类型：
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作者：
Ali YF;El-Morshedy S;Imam AA;Abdelrahman NI;Elsayed RM;Alkholy UM;Abdalmonem N;Shehab MM
评价血清Apelin作为早产儿视网膜病变（ROP）诊断工具的作用。38名胎龄范围为30 - 36周的早产儿（60%为男性）被纳入沙特阿拉伯KJO医院新生儿重症监护室，经证实诊断为ROP。另外，27例无ROP的早产儿作为对照。研究中的所有新生婴儿均接受充分的病史采集、全面的临床检查和通过间接检眼镜进行的眼底检查（在4-6周时），以及在出生时和4-6周龄时测定血清爱帕琳素。氧疗时间超过7天、剖宫产、败血症、机械通气、输血、胎膜早破、气胸、围产期窒息、心脏问题和新生儿黄疸被认为是ROP发生的危险因素。在疾病诊断时（4-6周），患者的血清爱帕琳素水平显著低于对照组（P<0.001），而在出生时的水平中没有观察到显著差异。血清Apelin对ROP的发生有重要的诊断价值。
To evaluate the role of serum apelin as a diagnostic tool in retinopathy of prematurity (ROP) disease. Thirty-eight preterm infants (60% male) with gestational age ranging from 30 to 36 weeks admitted to the neonatal intensive care unit, KJO Hospital, Saudi Arabia with proven diagnosis of ROP were included in the study. In addition, 27 preterm infants without ROP served as controls. All newborn infants in the study were subjected to adequate history taking, full clinical examination, and fundus examination by indirect ophthalmoscope (at 4–6 weeks) as well as determination of serum apelin at birth and at 4–6 weeks of age. The study revealed that oxygen therapy longer than 7 days’ duration, cesarean section (as a mode of delivery), sepsis, mechanical ventilation, blood transfusion, premature rupture of membranes, pneumothorax, perinatal asphyxia, cardiac problems, and neonatal jaundice were considered as risk factors related to development of ROP. Serum apelin levels were significantly lower in patients than controls (P<0.001) at time of diagnosis of the disease (4–6 weeks) while no significant differences were observed in levels at birth. Serum apelin was found to be of significant diagnostic value in the occurrence of ROP.