Expression of estrogen receptor-related receptor isoforms and clinical significance in endometrial adenocarcinoma
Expression of estrogen receptor-related receptor isoforms and clinical significance in endometrial adenocarcinoma
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DOI：
10.1111/j.1525-1438.2006.00527.x
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发表时间：
2006-03-01
影响因子：
4.8
通讯作者：
Wei, L
中科院分区：
文献类型：
--
作者：
Gao, M;Sun, P;Wei, L
雌激素受体相关受体（ERRs）是与雌激素受体（ERs）密切相关的孤儿核受体成员。研究表明，ERRs与雌激素反应元件结合并干扰ER信号通路。因此，它可能与雌激素依赖性疾病有关。本研究的目的是探讨ERRs是否参与子宫内膜腺癌的肿瘤发生。我们采用半定量逆转录 - 聚合酶链反应和免疫组织化学方法检测了ERRs在子宫内膜腺癌和正常子宫内膜中的表达。回顾了包括国际妇产科联盟（FIGO）分期、组织学分级、肌层浸润和淋巴结转移在内的临床病理特征。结果显示，ERRα、ERRβ和ERRγ的信使核糖核酸（mRNA）水平与免疫反应性呈正相关（分别为P = 0.009、P = 0.014和P = 0.001）。ERα阳性子宫内膜腺癌中ERRα mRNA的表达率和相对水平低于正常子宫内膜（P = 0.049和P = 0.023），而ERα阳性子宫内膜腺癌中ERRγ mRNA的相对水平高于正常子宫内膜（P = 0.014）。ERRα mRNA的表达与FIGO分期（P = 0.019）和肌层浸润（P = 0.043）呈正相关。ERRγ mRNA的表达与淋巴结转移呈负相关（P = 0.021）。结果表明，ERRα和ERRγ可能参与子宫内膜腺癌的肿瘤发生。ERRα和ERRγ有望成为子宫内膜腺癌新的预后因素。
Estrogen receptor-related receptors (ERRs) are members of orphan nuclear receptors closely related to the estrogen receptors (ERs). Researches showed that the ERRs bound to estrogen response elements and interfered in the ER signal pathway. Therefore, it might be associated with estrogen-dependent diseases. The purpose of this study was to explore whether ERRs were involved in the tumorigenesis of endometrial adenocarcinoma. We examined the expression of ERRs in endometrial adenocarcinoma and normal endometrium using semiquantitative reverse transcription-polymerase chain reaction and immunohistochemistry. Clinicopathologic features including FIGO stage, histologic grade, myometrial invasion, and nodal metastasis were reviewed. Results showed that messenger RNA (mRNA) levels of ERR alpha, ERR beta, and ERR gamma were positively associated with the immunoreactivities (P = 0.009, P = 0.014, and P = 0.001, respectively). The expression rate and relative level of ERR alpha mRNA in ER alpha-positive endometrial adenocarcinomas were lower than in normal endometriums (P = 0.049 and P = 0.023), whereas the relative level of ERR gamma mRNA in ER alpha-positive endometrial adenocarcinomas was higher than in normal endometriums (P = 0.014). Expression of ERR alpha mRNA was positively correlated with FIGO stage (P = 0.019) and myometrial invasion (P = 0.043). A negative correlation was observed between expression of ERR gamma mRNA and nodal metastasis (P = 0.021). Results suggested that ERR alpha and ERR gamma might participate in the tumorigenesis of endometrial adenocarcinoma. ERR alpha and ERR gamma are promising to be new prognostic factors in endometrial adenocarcinoma.