T cell exhaustion: from pathophysiological basics to tumor immunotherapy.
T cell exhaustion: from pathophysiological basics to tumor immunotherapy.
复制标题
DOI：
10.1186/s12964-016-0160-z
复制
发表时间：
2017-01-05
期刊：
影响因子：
--
通讯作者：
Geisberger R
中科院分区：
文献类型：
--
作者：
Catakovic K;Klieser E;Neureiter D;Geisberger R
免疫系统能够区分危险和非危险信号，从而诱导对病原体和癌症的适当免疫反应，或诱导自身耐受以避免自身免疫和免疫病理。为了防止免疫系统的破坏，已进化出的机制之一是功能性地沉默效应性T细胞，称为T细胞耗竭，病毒和癌症也利用T细胞耗竭来逃避免疫。在本文中，我们讨论了与T细胞耗竭相关的一些表型标记，并总结了目前通过使用单抗阻断这些表面标记来重振耗尽T细胞的策略。
The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoimmunity and immunopathology. One of the mechanisms that have evolved to prevent destruction by the immune system, is to functionally silence effector T cells, termed T cell exhaustion, which is also exploited by viruses and cancers for immune escape In this review, we discuss some of the phenotypic markers associated with T cell exhaustion and we summarize current strategies to reinvigorate exhausted T cells by blocking these surface marker using monoclonal antibodies.