Morphological and morphometric study on sphenoid and basioccipital ossification in normal human fetuses
Morphological and morphometric study on sphenoid and basioccipital ossification in normal human fetuses
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DOI：
10.1111/j.1741-4520.2011.00322.x
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发表时间：
2011-09-01
影响因子：
1.3
通讯作者：
Otani, Hiroki
中科院分区：
文献类型：
--
作者：
Zhang, Qinghua;Wang, Hui;Otani, Hiroki
脑的先天性异常通常对应于颅底异常，详细描述发育中颅底的形态学和个体差异对于诊断异常具有临床重要性。人类颅底的发育已经通过解剖、计算机断层扫描和磁共振成像进行了研究，每种方法都有其优点和缺点。我们在这里研究了正常人胎儿颅底骨染色，它允许直接观察骨化中心和精确的三维测量的发展。我们观察了22例正常福尔马林固定的人胎儿的蝶骨和基底枕骨，冠臀长度（CRL）为115-175 mm。我们定义了标志，并使用细卡尺测量蝶骨和基底枕骨。获得了这些骨化骨的生长模式，我们发现了生长模式之间的相似性和差异。我们还观察到个体的骨化模式的差异，特别是，单或双骨化中心模式的基蝶骨。两种模式组之间的眶蝶和蝶底宽度和宽度与总颅底宽度的比值存在显著差异，而其他测量值及其与总颅底的比值在两组之间没有差异。我们测量了22例CRL为105-186 mm的不同胎龄的人胎大脑和脑桥，发现大脑和脑桥的发育与颅底相应部位的发育密切相关。本研究结果有助于对人胎儿颅底发育过程中的生长模式和变化提供定量和定性的信息。
Congenital anomalies of the brain frequently correspond to cranial base anomalies, and a detailed description of morphology and individual variations in the developing cranial base is of clinical importance for diagnosing anomalies. Development of the human cranial base has been studied using dissection, computed tomography, and magnetic resonance imaging, each of which has advantages and disadvantages. We here examined development of the normal human fetal cranial base using bone staining, which allows for direct observation of the ossification centers and precise three-dimensional measurements. We observed alizarin red S-stained sphenoids and basiocciputs of 22 normal formalin-fixed human fetuses with crown-rump lengths (CRL) of 115-175 mm. We defined landmarks and measured sphenoids and basiocciputs using a fine caliper. Growth patterns of these ossifying bones were obtained, and we found similarities and differences among the growth patterns. We also observed individual variations in the ossification patterns, in particular, single-or double-ossification center patterns for the basisphenoid. The orbitosphenoid and basisphenoid widths and ratios of the widths to the total cranial base width were significantly different between the two pattern groups, whereas the other measurements and their ratios to the total cranial base did not differ between the groups. We measured the cerebrum and pons in different sets of 22 human fetuses with CRLs of 105-186 mm and found close relationships with the development of corresponding parts of the cranial base. The results contribute to the quantitative and qualitative information about the growth patterns and variations during human fetal cranial base development.