A prospective study of dietary acrylamide intake and the risk of endometrial ovarian, and breast cancer
A prospective study of dietary acrylamide intake and the risk of endometrial ovarian, and breast cancer
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DOI：
10.1158/1055-9965.epi-07-0581
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发表时间：
2007-11-01
影响因子：
3.8
通讯作者：
van den Brandt, Piet A.
中科院分区：
文献类型：
--
作者：
Hogervorst, Janneke G.;Schouten, Leo J.;van den Brandt, Piet A.
背景：丙烯酰胺是一种可能的人类致癌物，2002年在各种热处理的富含碳水化合物的食品中被检测到。到目前为止所做的少数流行病学研究还没有显示出与癌症的关系。我们的目的是调查丙烯酰胺摄入量和子宫内膜癌，卵巢癌，乳腺癌risk.Methods：荷兰队列研究饮食和癌症包括62,573名妇女，年龄在55-69岁之间。在基线（1986年），使用病例队列分析方法随机选择了2,589名妇女进行分析。亚组群成员和病例的丙烯酰胺摄入量评估与食物频率问卷，并基于所有相关的荷兰食品的化学分析。亚组分析从不吸烟者，以消除吸烟的影响，丙烯酰胺的一个重要来源。结果：经过11.3年的随访，327，300，和1,835例子宫内膜癌，卵巢癌，乳腺癌，分别记录。与丙烯酰胺摄入量最低的五分位数相比（平均摄入量，8.9微克/天），子宫内膜癌、卵巢癌和乳腺癌的多变量校正风险率比（FIR）最高五分位数（平均摄入量，40.2 μ g/天）为1.29 [95%置信区间（95% CI），0.81-2.07; P趋势= 0.181，1.78（95% CI，1.10-2.88; P趋势= 0.02）和0.93（95% CI，0.73-1.19; P趋势= 0.79）。对于从不吸烟者，相应的HR为1.99（95% CI，1.12-3.52; P趋势= 0.03），2.22（95% CI，1.204.08; P趋势= 0.01）和1.10（95%CI，0.80-1.52; P趋势= 0.55）。我们观察到绝经后子宫内膜癌和卵巢癌的风险随着饮食中丙烯酰胺摄入量的增加而增加，特别是在从不吸烟者中。患乳腺癌的风险与丙烯酰胺摄入量无关。
Background: Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. The few epidemiologic studies done thus far have not shown a relationship with cancer. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer risk.Methods: The Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline (1986), a random subcohort of 2,589 women was selected using a case cohort analysis approach for analysis. The acrylamide intake of subcohort members and cases was assessed with a food frequency questionnaire and was based on chemical analysis of all relevant Dutch foods. Subgroup analyses were done for never-smokers to eliminate the influence of smoking; an important source of acrylamide.Results: After 11.3 years of follow-up, 327, 300, and 1,835 cases of endometrial, ovarian, and breast cancer, respectively, were documented. Compared with the lowest quintile of acrylamide intake (mean intake, 8.9 mu g/day), multivariable-adjusted hazard rate ratios (FIR) for endometrial, ovarian, and breast cancer in the highest quintile (mean intake, 40.2 mu g/day) were 1.29 [95% confidence interval (95% CI), 0.81-2.07; P-trend = 0.181, 1.78 (95% CI, 1.10-2.88; P-trend = 0.02), and 0.93 (95% CI, 0.73-1.19; P-trend = 0.79), respectively. For never-smokers, the corresponding HRs were 1.99 (95% CI, 1.12-3.52; P-trend = 0.03), 2.22 (95% CI, 1.204.08; P-trend = 0.01), and 1.10 (95% CI, 0.80-1.52; P-trend = 0.55).ConCIusions: We observed increased risks of postmenopausal endometrial and ovarian cancer with increasing dietary acrylamide intake, particularly among never-smokers. Risk of breast cancer was not associated with acrylamide intake.