Age differences in the frontoparietal cognitive control network: implications for distractibility.
Age differences in the frontoparietal cognitive control network: implications for distractibility.
复制标题
额顶认知控制网络的年龄差异：对注意力分散的影响。
DOI：
10.1016/j.neuropsychologia.2012.05.025
复制
发表时间：
2012-07
期刊：
影响因子：
2.6
通讯作者：
Hasher L
中科院分区：
文献类型：
--
作者：
Campbell KL;Grady CL;Ng C;Hasher L
现有证据表明，由于基于额叶的控制机制随年龄增长而衰退，老年人对干扰性刺激的抑制能力降低，且对其内隐记忆更强。在这项研究中，我们利用功能性磁共振成像（fMRI）来检测注意力控制的神经基础方面的年龄差异，以及它们与分心程度差异和对干扰的后续记忆之间的关系。给老年人和年轻人快速呈现一系列叠加在物体上的单词或非单词，并要求他们对字母或物体进行1 - back任务，同时忽略另一种形式。在1 - back任务中，老年人比年轻人更容易因重叠的单词而分心，并且他们随后在一项内隐记忆任务中对这些单词表现出更强的启动效应。对成像数据的多变量分析揭示了一组区域，包括喙侧前额叶皮质和顶下小叶，在忽略单词条件下，年轻人比老年人激活程度更高，并且这组区域的活动与干扰单词的启动效应呈负相关。利用左右喙侧前额叶皮质作为种子点进行的功能连接性分析揭示了一个假定的控制区域网络，包括双侧顶叶皮质，在静息状态下与额叶种子点相连。老年人在这个额顶网络内的功能连接性降低，这表明他们更容易分心可能是由于一个通常用于减少干扰的认知控制网络内的活动和连贯性降低所致。
Current evidence suggests that older adults have reduced suppression of, and greater implicit memory for, distracting stimuli, due to age-related declines in frontal-based control mechanisms. In this study, we used fMRI to examine age differences in the neural underpinnings of attentional control and their relationship to differences in distractibility and subsequent memory for distraction. Older and younger adults were shown a rapid stream of words or nonwords superimposed on objects and performed a 1-back task on either the letters or the objects, while ignoring the other modality. Older adults were more distracted than younger adults by the overlapping words during the 1-back task, and they subsequently showed more priming for these words on an implicit memory task. A multivariate analysis of the imaging data revealed a set of regions, including the rostral PFC and inferior parietal cortex, that younger adults activated to a greater extent than older adults during the ignore-words condition, and activity in this set of regions was negatively correlated with priming for the distracting words. Functional connectivity analyses using right and left rostral PFC seeds revealed a network of putative control regions, including bilateral parietal cortex, connected to the frontal seeds at rest. Older adults showed reduced functional connectivity within this frontoparietal network, suggesting that their greater distractibility may be due to decreased activity and coherence within a cognitive control network that normally acts to reduce interference from distraction.