How Long Does It Take to Establish a Morphogen Gradient?
How Long Does It Take to Establish a Morphogen Gradient?
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DOI：
10.1016/j.bpj.2010.07.045
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发表时间：
2010-10-20
影响因子：
3.4
通讯作者：
Shvartsman, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Berezhkovskii, Alexander M.;Sample, Christine;Shvartsman, Stanislav Y.
形态发生梯度被定义为作为细胞分化的剂量依赖性调节剂的分子的浓度场。形态梯度研究的关键问题之一是它们是否在与发育模式相关的时间尺度上达到稳定状态。我们提出了一个系统的方法来解决这个问题，并说明它通过分析几个模型，占当地产生的化学信号的扩散和降解。
A morphogen gradient is defined as a concentration field of a molecule that acts as a dose-dependent regulator of cell differentiation. One of the key questions in studies of morphogen gradients is whether they reach steady states on time-scales relevant for developmental patterning. We propose a systematic approach for addressing this question and illustrate it by analyzing several models that account for diffusion and degradation of locally produced chemical signals.