Risk to all or none? A comparative analysis of controversies in the health risk assessment of Bisphenol A
Risk to all or none? A comparative analysis of controversies in the health risk assessment of Bisphenol A
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DOI：
10.1016/j.reprotox.2009.11.007
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发表时间：
2010-04-01
影响因子：
3.3
通讯作者：
Hanberg, Annika
中科院分区：
文献类型：
--
作者：
Beronius, Anna;Ruden, Christina;Hanberg, Annika
双酚A （BPA）是一种内分泌干扰物，其健康风险评估一直存在争议。关于双酚a健康风险的结论在“对任何部分人口没有风险”和“对全体人口有风险”的评估之间存在差异。我们进行了一项文献研究，调查这些差异的科学和/或政策相关原因。对双酚a的10项风险评估进行了仔细审查，并对评估之间的几个因素进行了比较，包括暴露水平的估计、关键研究和NOAEL的确定、评估因素和低剂量效应报告的重要性。结论的差异主要受到低剂量效应评估和这些数据对健康风险评估意义的不确定性的影响。结果说明了风险评估政策和专家判断的差异对风险评估过程的影响，并强调了透明度在这一过程中的重要性。(C) 2009爱思唯尔公司版权所有。
Bisphenol A (BPA) is an endocrine disruptor for which health risk assessment has proven controversial. Conclusions regarding health risks of BPA vary between assessments from "there is no risk to any part of the population" to "there is risk to the entire population". We have carried out a literature study investigating what might be the scientific and/or policy-related reasons for these differences. Ten risk assessments for BPA were scrutinized and several factors were compared between assessments, including estimations of exposure levels, identification of critical study and NOAEL, assessment factors and significance attributed to reports of low-dose effects. Differences in conclusions were mainly influenced by the evaluation of low-dose effects and the uncertainties surrounding the significance of these data for health risk assessment. The results illustrate the impact of differences in risk assessment policy and expert judgment on the risk assessment process and highlight the importance of transparency in this process. (C) 2009 Elsevier Inc. All rights reserved.