Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women
Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women
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DOI：
10.1002/dmrr.540
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发表时间：
2005-09-01
影响因子：
8
通讯作者：
Toyoshima, H
中科院分区：
文献类型：
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作者：
Mabuchi, T;Yatsuya, H;Toyoshima, H
瘦素的造血或促炎作用已被实验报道。我们调查了血清瘦素浓度是否与白色血细胞（WBC）计数在human.Methods日本公务员年龄在40至59岁（1082名男性和200名女性）的血清瘦素浓度进行了分析，他们的白细胞计数。采用放射免疫分析法和全自动粒子计数器分别测定血清瘦素浓度和白细胞计数，样本来自参与者每年健康体检时获得的样本。（几何标准差）瘦素浓度分别为3.25 +/- 1.82 ng/mL和6.25 +/- 3.99 ng/mL，几何平均WBC计数，男性5770 ± 1269/mm（3），女性5107 ± 1228/mm（3）。根据年龄、体重指数（BMI）、体力活动、饮酒和吸烟习惯调整的WBC计数随着瘦素浓度的增加而增加。通过瘦素浓度和这些协变量对WBC计数的多元线性回归显示，瘦素浓度与血清瘦素浓度显著且独立相关，特别是在女性中（标准化β = 0.31，p < 0.001），并且在男性中也是如此（标准化β = 0.17，p < 0.001）。BMI是没有显着相关性与白细胞计数的多变量模型调整瘦素水平在both sexual.Conclusions我们的研究结果是符合瘦素的造血或促炎功能。在肥胖人群中经常观察到的白细胞计数增加将由瘦素浓度增加介导。版权所有（C）2005约翰威利父子有限公司
Background Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans.Methods Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were analyzed in relation to their WBC count. Serum leptin concentrations and WBC counts were measured by radioimmunoassay and automated particle counter respectively, using samples obtained at the time of the participants' annual health checkups.Results The geometric mean ( geometric standard deviation) leptin concentrations were 3.25 +/- 1.82 ng/mL and 6.25 +/- 3.99 ng/mL, and the geometric mean WBC counts, 5770 +/- 1269/mm(3) and 5107 +/- 1228/mm(3), in men and women respectively. The WBC count adjusted for age, body mass index (BMI), physical activity, and drinking and smoking habits increased together with the increase in leptin concentration. Multiple linear regression against WBC count by the leptin concentration and those covariates revealed a significant and independent association with serum leptin concentration especially in women (standardized beta = 0.31, p < 0.001), and also in men (standardized beta = 0.17, p < 0.001). BMI was not significantly associated with WBC counts in the multivariate model adjusting for leptin levels in both sexes.Conclusions Our results are in line with leptin's hematopoietic or proinflammatory functions. The increased WBC counts often observed in obese people would be mediated by the increased leptin concentration. Ltd. Copyright (C) 2005 John Wiley & Sons, Ltd.