PseudoGeneQuest - Service for identification of different pseudogene types in the human genome
PseudoGeneQuest - Service for identification of different pseudogene types in the human genome
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DOI：
10.1186/1471-2105-9-299
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发表时间：
2008-07-02
影响因子：
3
通讯作者：
Vihinen, Mauno
中科院分区：
文献类型：
--
作者：
Ortutay, Csaba;Vihinen, Mauno
背景：假基因，即基因的非功能性拷贝，由于缺乏进化压力而快速进化，因此以几种不同的形式出现。 PseudoGeneQuest 是一种在线工具，用于搜索人类基因组中给定的查询序列，并识别不同类型的假基因以及新基因和基因片段。 描述：该服务可以检测由逆转录转座或片段基因组复制产生的假基因，其中许多未在公共假基因数据库中列出。该服务具有用户友好的网络界面，并使用强大的计算机集群来执行并行搜索，并在进行详尽的数据库搜索和分析的情况下提供相对较快的运行时间。结论：PseudoGeneQuest 是一种用于从人类基因组中检测新型假基因候选物的多功能工具。该服务搜索人类基因组序列中的五种类型的假基因，并提供可以轻松进一步分析观察结果的输出。除了结果文件之外，系统还提供链接到 Ensembl Genome Browser 的结果可视化。 PseudoGeneQuest 服务是免费提供的。
Background: Pseudogenes, nonfunctional copies of genes, evolve fast due the lack of evolutionary pressures and thus appear in several different forms. PseudoGeneQuest is an online tool to search the human genome for a given query sequence and to identify different types of pseudogenes as well as novel genes and gene fragments.Description: The service can detect pseudogenes, that have arisen either by retrotransposition or segmental genome duplication, many of which are not listed in the public pseudogene databases. The service has a user-friendly web interface and uses a powerful computer cluster in order to perform parallel searches and provide relatively fast runtimes despite exhaustive database searches and analyses.Conclusion: PseudoGeneQuest is a versatile tool for detecting novel pseudogene candidates from the human genome. The service searches human genome sequences for five types of pseudogenes and provides an output that allows easy further analysis of observations. In addition to the result file the system provides visualization of the results linked to Ensembl Genome Browser. PseudoGeneQuest service is freely available.