Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats
Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats
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DOI：
10.1016/j.brainres.2005.09.011
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发表时间：
2005-11-16
期刊：
影响因子：
2.9
通讯作者：
Vink, R
中科院分区：
文献类型：
--
作者：
O'Connor, CA;Cernak, I;Vink, R
与男性相比，女性在实验性脑外伤后脑水肿减少，尽管关于这是由于雌激素还是黄体酮，存在相互矛盾的报道。在本研究中，我们在雄性和去卵巢的雌性大鼠中证明，在弥漫性创伤性脑损伤后30分钟，单次生理剂量的任一激素均可减少血脑、屏障通透性和水肿的形成。我们得出结论，这两种激素可能有助于减少女性脑损伤后的水肿。(c) 2005 Elsevier B.V.版权所有
Females have reduced brain edema compared to males after experimental brain trauma, although contradictory reports exist as to whether this is due to either estrogen or progesterone. In the present study, we demonstrate in both male and ovariectomized female rats that a single physiological dose of either hormone at 30 min after diffuse traumatic brain injury reduces both blood brain,barrier permeability and edema formation. We conclude that both hormones may contribute to reduce edema in females after brain injury. (c) 2005 Elsevier B.V. All rights reserved.