Stimulation of collagen production by transforming growth factor-β1 during differentiation of cardiac fibroblasts to myofibroblasts
Stimulation of collagen production by transforming growth factor-β1 during differentiation of cardiac fibroblasts to myofibroblasts
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DOI：
10.1161/hy0202.103268
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发表时间：
2002-02-01
期刊：
影响因子：
8.3
通讯作者：
Lijnen, PJ
中科院分区：
文献类型：
--
作者：
Petrov, VV;Fagard, RH;Lijnen, PJ
本研究的目的是阐明转化生长因子-β(1)如何通过刺激成纤维细胞、通过肌成纤维细胞或通过成纤维细胞向肌成纤维细胞分化来促进间质细胞在心肌组织中的胶原沉积。在培养的第二代成年大鼠心脏成纤维细胞中，研究了对胶原合成和α-平滑肌肌动蛋白(α-SMA)表达的剂量和时间依赖性的刺激作用。转化生长因子-β(1)刺激的胶原生成呈正相关(r=0.68，P
The aim of the present study was to elucidate how transforming growth factor-beta(1) (TGF-beta(1)) can stimulate collagen deposition in cardiac tissue by interstitial cells via stimulation of fibroblasts, via myofibroblasts, or via differentiation of Fibroblasts to myofibroblasts. The dose- and time-dependent stimulation of collagen production and of expression of alpha-smooth muscle actin (alpha-SMA), a marker of myofibroblasts, was studied in cultures of second-passage adult rat cardiac fibroblasts. The TGF-beta(1)-stimulated collagen production is positively correlated (r=0.68, P