Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia
Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia
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DOI：
10.1016/j.envres.2015.11.029
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发表时间：
2016-10-01
影响因子：
8.3
通讯作者：
Kannan, Kurunthachalam
中科院分区：
文献类型：
--
作者：
Asimakopoulos, Alexandros G.;Xue, Jingchuan;Kannan, Kurunthachalam
氧化应激产生于体内过量的自由基，是许多疾病的触发因素，如癌症和动脉粥样硬化。暴露于环境化学物质的增加可能会导致氧化应激。然而，暴露于外源性物质和氧化应激之间的关联很少被研究。在这项研究中，在沙特阿拉伯吉达的人群中测定了57种外源性物质（抗菌剂、对羟基苯甲酸酯、双酚、二苯甲酮和邻苯二甲酸酯代谢物）的尿液浓度，以描述与氧化应激生物标志物8-羟基-2 '-脱氧鸟苷（8 OHDG）的相关性。我们收集了130份尿样，并使用液相色谱串联质谱（LC/MS/MS）方法分析了57种外源性物质。未调整和肌酐或比重调整浓度的外源性物质和80 HDG之间的关联进行了检查皮尔逊相关性和多元回归分析。在尿液中发现高浓度的mCPP（邻苯二甲酸二正辛酯的代谢物; DnOP）和mCMHP（邻苯二甲酸二乙基己酯的代谢物; DEHP）。此外，双酚S（BPS）的浓度高于双酚A（BPA）。DEHP、邻苯二甲酸、BPA、BPS和甲基原儿茶酸的代谢产物浓度与80 FIDG显著相关。这是第一项生物监测研究，报告了沙特人口接触各种环境化学品的情况，并提供了环境化学品接触有助于氧化应激的证据。(C)2015 Elsevier Inc. All rights reserved.
Oxidative stress arises from excessive free radicals in the body and is a trigger for numerous diseases, such as cancer and atherosclerosis. Elevated exposure to environmental chemicals can contribute to oxidative stress. The association between exposure to xenobiotics and oxidative stress, however, has rarely been studied. In this study, urinary concentrations of 57 xenobiotics (antimicrobials, parabens, bisphenols, benzophenones, and phthalates metabolites) were determined in a population from Jeddah, Saudi Arabia, to delineate association with the oxidative stress biomarker, 8-hydroxy-2'-deoxyguanosine (8OHDG). We collected 130 urine samples and analyzed for 57 xenobiotics using liquid chromatography tandem mass spectrometry (LC/MS/MS) methods. The association between unadjusted and creatinine- or specific gravity-adjusted concentrations of xenobiotics and 80HDG was examined by Pearson correlations and multiple regression analysis. High concentrations of mCPP (a metabolite of di-n-octyl phthalate; DnOP) and mCMHP (a metabolite of diethylhexyl phthalate; DEHP) were found in urine. In addition, the concentrations of bisphenol S (BPS) were higher than those of bisphenol A (BPA). The concentrations of metabolites of DEHP, phthalic acid, BPA, BPS, and methyl-protocatechuic acid were significantly associated with 80FIDG. This is the first biomonitoring study to report exposure of the Saudi population to a wide range of environmental chemicals and provides evidence that environmental chemical exposures contribute to oxidative stress. (C) 2015 Elsevier Inc. All rights reserved.