T1 Map of Post-Myocardial Infarction for Precise Tissue Characterization.
T1 Map of Post-Myocardial Infarction for Precise Tissue Characterization.
复制标题
心肌梗死后的 T1 图，用于精确的组织表征。
DOI：
10.1161/circimaging.117.006835
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Yang,PhillipC
中科院分区：
文献类型：
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作者：
Youssef,AmrA;Yang,PhillipC
结论在9.4 T条件下，以3× 3 cm视场对平均心率为bbb500 bpm的小鼠进行成像，在80分钟的扫描时间内获得0.12× 0.12 mm的平面内空间分辨率，克服了许多挑战，值得祝贺。然而，出于同样的确切原因，上述限制可能会使该技术远离具有可重复结果的临床应用的转化努力。虽然这种方法很有前景，但需要在较低的视野下使用临床扫描仪进行研究，以确定该技术是否能够快速全面地分析心肌损伤，并为有效的梗死后治疗提供有意义的患者特异性预后数据。心肌损伤的时空变化应在临床研究中得到证实，并与心血管事件相关。这些问题必须得到解决，以提供更有效的CMR技术来推进心肌梗死患者的预测性诊断。
ConclusionsIn conclusion, the authors must be congratulated in overcoming the many challenges of imaging mice with average heart rate of> 500 bpm at 9.4 T with 3× 3 cm field of view to obtain an excellent in-plane spatial resolution of 0.12× 0.12 mm in a scan time of 80 minutes. However, for the same exact reasons, the above-mentioned limitations may distance this technique from the translational efforts to achieve clinical application with reproducible findings. While promising, this method needs to be studied at a lower field with clinical scanners to determine whether this technique will allow a fast and comprehensive analysis of myocardial injury and provide meaningful patient-specific prognostic data for effective postinfarction therapy. The temporal and spatial changes of myocardial injury should be confirmed in clinical studies and correlated with cardiovascular events. These issues must be addressed to provide a more effective CMR technique to advance the predictive diagnosis of the patients who experience MI.