MODIFICATION BY BEET AND CABBAGE DIETS OF AFLATOXIN B1-INDUCED RAT PLASMA ALPHA-FETOPROTEIN ELEVATION, HEPATIC TUMORIGENESIS, AND MUTAGENICITY OF URINE
MODIFICATION BY BEET AND CABBAGE DIETS OF AFLATOXIN B1-INDUCED RAT PLASMA ALPHA-FETOPROTEIN ELEVATION, HEPATIC TUMORIGENESIS, AND MUTAGENICITY OF URINE
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DOI：
10.1016/s0278-6915(82)80008-2
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发表时间：
1982-01-01
影响因子：
4.3
通讯作者：
STOEWSAND, GS
中科院分区：
文献类型：
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作者：
BOYD, JN;BABISH, JG;STOEWSAND, GS
给断奶的雄性 Fischer 大鼠喂食纯化饮食或含有 25%（wt/wt）冻干甜菜或卷心菜（含或不含 1 ppm 黄曲霉毒素 B1 (AFB1)）的饮食，持续 26 周。 3-7周后，卷心菜饮食减少，而甜菜饮食则增强AFB1诱导的血浆甲胎蛋白(AFP)升高。当通过将动物维持纯化（基础）饮食另外16周将实验延长至42周时，食用甜菜饮食中的AFB1的大鼠有72.+-。 14个肿瘤/肝脏（肿瘤平均表面直径，6.13±4.69毫米）；在对照饮食中给予 AFB1 的动物有 30.+-。 16 个肿瘤/肝脏（平均表面直径，4.36 ± 3.16 毫米）；在卷心菜饮食中摄入 AFB1 的大鼠有 13 .+- 。 5 个肿瘤/肝脏（平均表面直径，4.28 ± 2.89 毫米）。在沙门氏菌/哺乳动物微粒体测试中，与用纯化饲料或卷心菜饲料喂养 AFB1 的大鼠的尿液相比，用甜菜喂养 AFB1 的大鼠的尿液在鼠伤寒沙门氏菌菌株 TA98 中引起显着（P < 0.05）更多的回复体。含甜菜和卷心菜的饮食对未接受 AFB1 的大鼠的血浆 AFP 浓度、肝肿瘤发生或尿液致突变性没有影响。常见蔬菜的非营养化合物可能会影响对化学致癌物的反应，AFP 测定可用于快速识别改变致癌作用的饮食因素。
Weanling male Fischer rats were fed a purified diet or diets containing 25% (wt/wt) freeze-dried ground beets or cabbage with or without 1 ppm aflatoxin B1 (AFB1) for 26 wk. In 3-7 wk the cabbage diet diminished, while the beet diet enhanced AFB1-induced plasma .alpha.-fetoprotein (AFP) elevation. When the experiment was extended to 42 wk by maintaining the animals on the purified (basal) diet for a further 16 wk the rats that had consumed AFB1 in the beet diet had 72 .+-. 14 tumors/liver (mean surface diameter of tumors, 6.13 .+-. 4.69 mm); animals that were given AFB1 in the control diet had 30 .+-. 16 tumors/liver (mean surface diameter, 4.36 .+-. 3.16 mm); rats that were given AFB1 in the cabbage diet had 13 .+-. 5 tumors/liver (mean surface diameter, 4.28 .+-. 2.89 mm). In the Salmonella/mammalian microsomal test, urine from rats fed AFB1 with beets caused significantly (P < 0.05) more revertants in S. typhimurium strain TA98 than did urine from rats fed AFB1 with purified or cabbage diets. The beet- and cabbage-containing diets had no effect on the plasma AFP concentration, hepatic tumorigenesis, or the mutagenicity of urine in rats receiving no AFB1. Non-nutrient compounds of common vegetables may influence the response to chemical carcinogens, and that AFP determinations are useful in the rapid identification of dietary factors that modify carcinogenesis.