Knowledge and adherence to antiretroviral therapy among adult people living with HIV/AIDS at Tikur Anbessa Specialized Hospital, Ethiopia
Knowledge and adherence to antiretroviral therapy among adult people living with HIV/AIDS at Tikur Anbessa Specialized Hospital, Ethiopia
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埃塞俄比亚 Tikur Anbessa 专科医院成人艾滋病毒/艾滋病患者的抗逆转录病毒治疗知识和依从性
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
W. Shibeshi
中科院分区：
文献类型：
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作者：
Ruth Demessie;Alemayehu Mekonnen;W. Amogne;W. Shibeshi
背景：坚持抗逆转录病毒治疗（ART）对于实现最佳病毒学反应、降低耐药风险以及降低发病率和死亡率是必要的。本研究的目的是评估患者对治疗计划和方案的了解程度，确定依从率并确定与不依从 ART 相关的因素。方法：在埃塞俄比亚亚的斯亚贝巴 Tikur Anbessa 专业教学医院进行了一项横断面研究，使用了 2013 年 3 月和 4 月期间半结构化访谈（自我报告）和 ART 数据库（药房补充）的数据，共有 350 名参与者。结果：结果表明，33% 的参与者对治疗计划和方案有很好的了解。根据自我报告和药房续药记录，分别有79.1%和72.9%的患者依从率≥95%。使用药房续药记录发现，年轻人不太可能坚持接受 ART（AOR [95%] = 0.51 [0.30, 0.85]）。使用自我报告的 ART 不依从性的危险因素包括使用记忆辅助工具 (AOR [95%] = 3.46 [1.72, 6.98])、治疗满意度 (AOR [95%] = 2.33 [1.22, 4.07])、联合用药 (AOR [95%] = 0.56 [0.32, 0.98]) 和方案转换（AOR [95%] = 0.41 [0.19, 0.85]）。而使用药房补充记录的危险因素包括：治疗计划和治疗方案的知识 (AOR [95%] = 2.50 [1.39, 4.51])、记忆辅助工具的使用 (AOR [95%] = 2.71 [1.34, 5.47])、治疗满意度 (AOR [95%] = 3.78 [1.47, 9.71]) 和治疗方案转换 (AOR) [95%] = 0.50 [0.27, 0.92]）。结论：年龄较大、对治疗计划和方案有充分了解、记忆辅助工具的使用、治疗满意度以及没有联合用药和方案转换表明对 ART 的依从性更高。
Background: Adherence to antiretroviral therapy (ART) is necessary to achieve best virological response, lower the risk of drug resistance, and reduce morbidity and mortality. The objectives of the current study were to assess the extent of knowledge of patients on treatment plan and regimen, determine the rate of adherence and identify factors related to non-adherence to ART. Methods: A cross-sectional study was conducted at Tikur Anbessa Specialized Teaching Hospital, Addis Ababa, Ethiopia, using data from both semi-structured interview (self-report) and ART database (pharmacy refill) during the months of March and April 2013 using a total 350 participants. Results: The results indicated that 33% of the participants had good knowledge on the treatment plan and regimen. Using self-report and pharmacy refill record, 79.1% and 72.9% respectively showed adherence rate of ≥95%. Younger people were found to be less likely to adhere to ART (AOR [95%] = 0.51 [0.30, 0.85]) using pharmacy refill record. Risk factors for ART non-adherence using self-report were use of memory aids (AOR [95%] = 3.46 [1.72, 6.98]), treatment satisfaction (AOR [95%] = 2.33 [1.22, 4.07]), taking co-medication (AOR [95%] = 0.56 [0.32, 0.98]), and regimen switch (AOR [95%] = 0.41 [0.19, 0.85]). Whereas using pharmacy refill record risk factors were, knowledge on treatment plan and regimen (AOR [95%] = 2.50 [1.39, 4.51]), use of memory aids (AOR [95%] = 2.71 [1.34, 5.47]), treatment satisfaction (AOR [95%] = 3.78 [1.47, 9.71]), and regimen switch (AOR [95%] = 0.50 [0.27, 0.92]). Conclusion: Older age, good knowledge on treatment plan and regimen, use of memory aids, treatment satisfaction, and not having co-medications and regimen switch showed more adherence to ART.