Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival
Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival
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DOI：
10.1200/jco.2001.19.2.577
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发表时间：
2001-01-15
影响因子：
45.3
通讯作者：
Reinhold, U
中科院分区：
文献类型：
--
作者：
Ugurel, S;Rappl, G;Reinhold, U
目的：确定血清血管生成因子血管生成素、血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）和白细胞介素-8（IL-8）对恶性黑色素瘤患者预后的预测价值。血管生成素，VEGF，bFGF，和IL-在125名患有不同疾病阶段的黑色素瘤患者的血清中测量了8个，并且使用或不使用当前治疗，包括干扰素α和不同的抗肿瘤药物。结果：与健康对照组相比，黑色素瘤患者血清血管生成素、VEGF、bFGF和IL-8水平均显著升高。血清VEGF、bFGF和IL-8浓度升高与晚期疾病分期和肿瘤负荷相关。患者的细胞抑制治疗伴随着血管生成素、bFGF和IL-8的血清水平升高。单变量分析显示，血清VEGF（P =.0001和.0036）、bFGF（P =.0001和.0036）水平升高，
Purpose: To determine the predictive value of the angiogenic serum factors angiogenin, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and interleukin-8 (IL-8) for the prognosis of patients with malignant melanoma.Patients and Methods: Angiogenin,VEGF, bFGF,and IL-8 were measured in sera of 125 melanoma patients with different stages of disease and with or without current therapy including interferon alfa and different cytostatics in comparison with 30 healthy controls using enzyme-linked immunosorbent assay.Results: Serum levels of angiogenin, VEGF, bFGF, and IL-8 were significantly increased in melanoma patients compared with healthy controls. Elevated serum concentrations of VEGF, bFGF, and IL-8 were associated with advanced disease stages and tumor burden. Cytostatic therapy of patients was accompanied by increased serum levels of angiogenin, bFGF, and IL-8. As shown by univariate analysis, elevated serum levels of VEGF (P =.0001 and .0036), bFGF (P