Highly enantioselective synthesis of polysubstituted tetrahydroquinolines via organocatalytic Michael/Aza-Henry tandem reactions.
Highly enantioselective synthesis of polysubstituted tetrahydroquinolines via organocatalytic Michael/Aza-Henry tandem reactions.
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DOI：
10.1021/ol103069d
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发表时间：
2011-02
期刊：
影响因子：
5.2
通讯作者：
Zhenhua Jia;Yong-Chun Luo;Peng‐Fei Xu
中科院分区：
文献类型：
--
作者：
Zhenhua Jia;Yong-Chun Luo;Peng‐Fei Xu
Highly enantioselective chiral bifunctional thiourea catalyzed asymmetric tandem reactions for synthesis of substituted tetrahydroquinolines are described. Substituted tetrahydroquinolines were given in good yields (up to 98%), high enantioselectivities (up to >99% ee), and diastereoselectivities (up to 20:1 dr).
