Spatial distribution of long-term potentiation in the surround of visual cortex lesions in vitro
Spatial distribution of long-term potentiation in the surround of visual cortex lesions in vitro
复制标题
体外视皮层病变周围长时程增强的空间分布
DOI：
10.1007/s00221-009-1964-5
复制
发表时间：
2009
影响因子：
2
通讯作者：
T. Mittmann
中科院分区：
文献类型：
--
作者：
C. Dohle;U. Eysel;T. Mittmann
局灶性视皮层损伤导致周围皮层网络的功能变化，可能通过突触长时程增强（LTP）介导。虽然已观察到损伤后LTP的易化，但对正常大鼠和局灶性损伤大鼠视皮层中LTP的空间分布尚不清楚。我们使用了64多电极阵列，以验证在第IV层的θ-突发刺激引起的LTP的传播。在对照组、假手术组和损伤组动物的视皮层中线的可比距离处进行测量。在对照组大鼠，LTP引起的投射到所有的视觉皮层层。然而，我们完全没有观察到假手术动物手术后1-4天的LTP。在可比的生存时间，没有LTP可以引起损伤治疗的大鼠在直接附近的损伤的边界，而LTP成功地诱导在更大的距离病变。这种恢复后病变LTP的最大范围在空间上比对照组更有限，并且在所有方向上都是相等的，因此绝对距离而不是连接的最大长度或密度似乎统治局部病变诱导的功能重塑。
Focal visual cortex lesions lead to functional changes in the surrounding cortical network, possibly mediated through synaptic long-term potentiation (LTP). Although a post-lesional facilitation of LTP has been observed, nothing is known about the spatial profile of LTP in the normal and focally lesioned visual cortex of rats. We used a 64-multielectrode array to characterise the spread of LTP induced by theta-burst stimulation in layer IV. Measurements were made at comparable distances from the midline in the visual cortex of controls, sham-operated and lesioned animals. In control rats, LTP was elicited in projections to all visual cortex layers. However, we completely failed to observe LTP in sham-operated animals 1–4 days after surgery. At comparable survival times, no LTP could be elicited in the lesion-treated rats in direct vicinity of the border of the injury, while LTP was successfully induced at larger distances from the lesion. The maximal reach of this restored post-lesion LTP was spatially more limited than in controls and equal in all directions, accordingly absolute distance and not maximal length or density of connections seems to rule local lesion-induced functional remodelling.
影响因子：
2.5
作者：
CHAGNACAMITAI, Y;CONNORS, BW
通讯作者：
CONNORS, BW