The therapeutic effect of bevacizumab on plaque neovascularization in a rabbit model of atherosclerosis during contrast-enhanced ultrasonography.
The therapeutic effect of bevacizumab on plaque neovascularization in a rabbit model of atherosclerosis during contrast-enhanced ultrasonography.
复制标题
超声造影时贝伐珠单抗对兔动脉粥样硬化模型斑块新生血管的治疗作用
DOI：
10.1038/srep30417
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发表时间：
2016-07-25
影响因子：
4.6
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Li Y;Zhu Y;Deng Y;Liu Y;Mao Y;Wang J;Sun J
该研究的目的是利用超声造影（CEUS）评估血管生成抑制剂贝伐珠单抗对兔模型不同阶段斑块的治疗效果。 55只兔子诱发腹主动脉粥样硬化。随机选取36只家兔根据贝伐单抗注射时间分为2组：早期斑块组（ESP组）和晚期斑块组（LSP组）。其余的人被认为是对照组。对腹主动脉进行标准超声检查和 CEUS 成像。 CEUS 后对动物实施安乐死，并采集斑块标本进行 CD31 的组织学染色。与ESP组和LSP组相比，对照组表现出明显更高的增强强度、斑块内增强强度与管腔内增强强度的比率更高以及斑块切片中CD31阳性微血管数量增加（均P<0.05）。与ESP组相比，LSP组的增强强度更高（P = 0.044），斑块内增强强度与管腔内增强强度的比率更高（P = 0.023），斑块切片中CD31阳性微血管更多（P = 0.006）。贝伐珠单抗对家兔早期斑块的新生血管形成具有更先进的抑制作用。
The purpose of the study was to assess the therapeutic effect of the angiogenesis inhibitor bevacizumab on plaques of various stages in rabbit models using contrast-enhanced ultrasonography (CEUS). Abdominal aortic atherosclerosis was induced in 55 rabbits. Thirty-six randomly selected rabbits were divided into 2 groups according to the timing of the bevacizumab injection: an early-stage plaque group (Group ESP) and a later-stage plaque group (Group LSP). The remainder were considered the control group. Standard ultrasonography and CEUS imaging of the abdominal aorta were performed. The animals were euthanized after CEUS and plaque specimens were harvested for histological staining of CD31. The control group exhibited a substantially higher enhanced intensity, a higher ratio of enhanced intensity in the plaque to that in the lumen and an increased number of CD31-positive microvessels in the plaque sections than Groups ESP and LSP (P < 0.05 for all). A higher enhanced intensity (P = 0.044), a higher ratio of enhanced intensity in the plaque to that in the lumen (P = 0.023) and more CD31-positive microvessels in the plaque sections (P = 0.006) were found in Group LSP than in Group ESP. Bevacizumab demonstrated more advanced inhibition of neovascularization in early-stage plaques in rabbits.
恩度对非小细胞肺癌患者颈软斑块新生血管的治疗作用
影响因子：
4.6
作者：
Pu Z;Wang Y;Zhang Y;Huang J;Hong Y;He H;Liu C;Chen S;Grayburn PA;Huang P
通讯作者：
Huang P