Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNγ-transduced tumor cell immunotherapy of experimental glioma
Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNγ-transduced tumor cell immunotherapy of experimental glioma
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DOI：
10.1016/j.jneuroim.2009.10.017
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发表时间：
2010-01-25
影响因子：
3.3
通讯作者：
Bengzon, Johan
中科院分区：
文献类型：
--
作者：
Gunnarsson, Salina;Bexell, Daniel;Bengzon, Johan
本研究报告了预先建立的实验性大鼠胶质瘤的消退，作为使用干扰素γ（IFN γ）转导的自体肿瘤细胞与局部瘤内递送的白细胞介素7（IL-7）的间充质基质细胞相结合的外周免疫的结果。单独的IL-7显著降低了肿瘤面积，并且这种效果在IFN γ免疫时增强。与单独接受细胞因子的大鼠相比，在接受联合治疗的动物中观察到更高密度的瘤内T细胞，这表明治疗效果取决于T细胞反应。(C)2009 Elsevier B. V.保留所有权利。
The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFN gamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFN gamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to rats receiving either cytokine alone suggesting that the therapeutic effect is dependent on a T-cell response. (C) 2009 Elsevier B.V. All rights reserved.