RELATIONSHIPS BETWEEN QUANTITATIVE PULSE-ECHO ULTRASOUND PARAMETERS FROM THE SUPERFICIAL ZONE OF THE HUMAN ARTICULAR CARTILAGE AND CHANGES IN SURFACE ROUGHNESS, COLLAGEN CONTENT OR COLLAGEN ORIENTATION CAUSED BY EARLY DEGENERATION
RELATIONSHIPS BETWEEN QUANTITATIVE PULSE-ECHO ULTRASOUND PARAMETERS FROM THE SUPERFICIAL ZONE OF THE HUMAN ARTICULAR CARTILAGE AND CHANGES IN SURFACE ROUGHNESS, COLLAGEN CONTENT OR COLLAGEN ORIENTATION CAUSED BY EARLY DEGENERATION
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DOI：
10.1016/j.ultrasmedbio.2017.03.015
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发表时间：
2017-08-01
影响因子：
2.9
通讯作者：
Kuroki, Hiroshi
中科院分区：
文献类型：
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作者：
Kiyan, Wataru;Ito, Akira;Kuroki, Hiroshi
我们的目的是定量研究基于振幅的脉冲回波超声参数和膝关节软骨早期退变之间的关系。使用15 MHz脉冲超声三维扫描系统离体评估了根据国际肱骨修复学会分级被判定为0级或1级的6个人股骨髁的20个样本。通过激光显微镜和傅里叶变换红外成像光谱仪测量软骨表面粗糙度（R-q）、平均胶原含量（A（1））和胶原取向（A（12））。使用线性混合效应模型（LMM）进行的多元回归分析显示，软骨表面的时域反射系数（Rc）与R-q和A（12）具有显著的决定系数（R-LMMm（2）= 0.79）;然而，R-c与A（1）不相关。关于浅表区的胶原特征，发现Rc是反映早期退变样品的胶原解体而不是胶原含量的敏感指标。(C)2017年世界医学和生物学超声联合会。
We aimed to quantitatively investigate the relationship between amplitude-based pulse-echo ultrasound parameters and early degeneration of the knee articular cartilage. Twenty samples from six human femoral condyles judged as grade 0 or 1 according to International Cartilage Repair Society grading were assessed using a 15-MHz pulsed-ultrasound 3-D scanning system ex vivo. Surface roughness (R-q), average collagen content (A(1)) and collagen orientation (A(12)) in the superficial zone of the cartilage were measured via laser microscopy and Fourier transform infrared imaging spectroscopy. Multiple regression analysis with a linear mixed-effects model (LMM) revealed that a time-domain reflection coefficient at the cartilage surface (Rc) had a significant coefficient of determination with R-q and A(12) (R-LMMm(2) = 0.79); however, R-c did not correlate with A(1). Concerning the collagen characteristic in the superficial zone, Rc was found to be a sensitive indicator reflecting collagen disorganization, not collagen content, for the early degeneration samples. (C) 2017 World Federation for Ultrasound in Medicine & Biology.