Rapid oligosaccharide synthesis on a fluorous support
Rapid oligosaccharide synthesis on a fluorous support
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DOI：
10.1016/j.tet.2004.07.027
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发表时间：
2004-09-27
期刊：
影响因子：
2.1
通讯作者：
Inazu, T
中科院分区：
文献类型：
--
作者：
Goto, K;Miura, T;Inazu, T
合成了一种新型含氟载体Hfb（六氟链型丁酰基）。Hfb基团容易引入到碳水化合物的异头羟基中，并且在裂解后可再循环。Hfb基团的使用适用于寡糖的快速合成，其中合成中间体可以使用氟和正常有机溶剂纯化。每个合成中间体可以通过TLC、NMR和质谱法监测。(C)2004爱思唯尔有限公司保留所有权利。
The novel fluorous support Hfb (hexakisfluorous chain-type butanoyl) was easily prepared. The Hfb group was readily introduced into the anomeric hydroxyl group of a carbohydrate, and was recyclable after cleavage. The use of the Hfb group was applicable for the rapid oligosaccharide synthesis in which the synthetic intermediates could be purified using fluorous and normal organic solvents. Each synthetic intermediate could be monitored by TLC, NMR and mass spectrometry. (C) 2004 Elsevier Ltd. All rights reserved.