Effect of surface treatment on the bioactivity of nickel-titanium
Effect of surface treatment on the bioactivity of nickel-titanium
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DOI：
10.1016/j.actbio.2008.05.010
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发表时间：
2008-11-01
影响因子：
9.7
通讯作者：
Knowles, Jonathan Campbell
中科院分区：
文献类型：
--
作者：
Chrzanowski, Wojciech;Abou Neel, Ensanya Ali;Knowles, Jonathan Campbell
本文评价了不同表面处理后的镍钛合金在不同介质（Hanks平衡盐溶液、Dulbecco改良Eagle介质和成骨介质）中的生物活性性能。将样品在相关介质中浸泡长达 24 小时后，根据 X 射线光电子能谱和原子力显微镜研究进行评估。这使得可以评估 Ca2+ 和 P5+ 沉淀的动力学以及介质与表面的早期相互作用。此外，还测量了表面自由能，并研究了热处理对相变温度以及镍和钛离子释放速率的影响。在 HBSS 中进行评估时，简单研磨的 Ni-Ti 样品观察到最有利的生物活性特性，其特性与参考阳性样品 (BioactiveTi) 相似。另一方面，在 600 摄氏度下热处理的样品显示出非常低水平的 Ca 和 P 沉淀。最有趣的是，在含有有机成分（蛋白质、维生素、抗生素和药物）的介质中进行的评估表明，无论表面处理方法如何，所有样品的生物活性都处于相同水平（参考阴性除外）。它证明有机成分与表面快速相互作用，形成薄薄的蛋白质层，这改变了样品的表面特性，使其具有生物活性。没有观察到 Ca2+ 和 P5+ 沉淀动力学的显着差异。然而，进一步的离子释放和化学成分评估表明，由于顶层（碱处理）中的镍含量非常高，并且镍释放率很高（火花氧化和碱处理），因此碱处理和火花氧化不能被视为对生物医学应用有用。 (C) 2008 Acta Materialia Inc. 由 Elsevier Ltd 出版。保留所有权利。
In this paper, the bioactive properties of Ni-Ti alloy after different surface treatments were evaluated in different media (Hanks' balanced salt solution, Dulbecco's modified Eagle's medium and osteogenic). Evaluation was performed on the basis of X-ray photoelectron spectroscopy and atomic force microscopy studies after immersing samples for up to 24 h in the relevant media. This allowed assessment of the kinetics of Ca2+ and P5+ precipitation and early interaction of the media with surfaces. In addition, the surface free energy was measured and the influence of heat treatment on phase transformation temperatures and rate of nickel and titanium ion release was investigated. The most favourable bioactive properties were observed for simply ground Ni-Ti samples when evaluated in HBSS, which showed similar properties to reference positive samples (BioactiveTi). On the other hand, samples heat-treated at 600 degrees C showed very low levels of precipitation of Ca and P. Most interestingly, evaluation in the media containing organic components (protein, vitamins, antibiotics and drugs) revealed that bioactivity for all the samples was at the same level (except for the reference negative) irrespective of the surface preparation method. It demonstrated that organic components interact with the surface rapidly, forming a thin protein layer, and this altered the surface properties of the samples, making them bioactive. No significant difference in kinetics of the Ca2+ and P5+ precipitation were observed. Nevertheless, further ion release and chemical composition evaluation revealed that alkali treatment and spark oxidation cannot be considered as a useful for biomedical application due to very high levels of Ni in the top layer (alkali-treated) and high rate of Ni release (spark-oxidized and alkali-treated). (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.