Drug Dissolution from Indomethacin‐starch Hybrid Powders Prepared by the Dry Impact Blending Method
Drug Dissolution from Indomethacin‐starch Hybrid Powders Prepared by the Dry Impact Blending Method
复制标题
干冲击混合法制备吲哚美辛淀粉杂化粉末的药物溶出
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
M. Koishi
中科院分区：
文献类型：
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作者：
T. Ishizaka;H. Honda;M. Koishi
摘要-吲哚美辛与马铃薯淀粉杂交，使用干冲击混合方法。通过扫描电子显微镜和X射线粉末衍射研究所得混合粉末。无定形吲哚美辛在杂交后立即在淀粉表面上铺展成层，然后逐渐恢复为牢固地粘附在淀粉表面上的细结晶颗粒。将混合粉末中的消炎痛溶出度与市售胶囊中的物理混合物和颗粒中的消炎痛溶出度进行比较。吲哚美辛从粉末和胶囊剂型中的溶出，即使在酸性介质中，也通过杂交显著加速。
Abstract— Indomethacin was hybridized with potato starch using a dry impact blending method. Resultant hybrid powders were investigated by scanning electron microscopy and X‐ray powder diffraction. Amorphous indomethacin spread over the starch surface in a layer immediately after being hybridized, and then gradually reverted to fine crystalline particles adhering firmly to the starch surface. Indomethacin dissolution from the hybrid powder was compared with those from physical mixtures and granules taken from a commercially available capsule. Indomethacin dissolution from powder and capsule dosage forms, even in an acidic medium, was drastically accelerated by the hybridization.