Induction of long-term receptive field plasticity in the auditory cortex of the waking guinea pig by stimulation of the nucleus basalis.
Induction of long-term receptive field plasticity in the auditory cortex of the waking guinea pig by stimulation of the nucleus basalis.
复制标题
通过刺激基底核诱导清醒豚鼠听觉皮层的长期感受野可塑性。
DOI：
10.1037//0735-7044.112.3.467
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发表时间：
1998
影响因子：
1.9
通讯作者：
Weinberger,NM
中科院分区：
文献类型：
--
作者：
Bjordahl,TS;Dimyan,MA;Weinberger,NM
学习可诱导初级听觉皮质神经元感受野的可塑性。这种可塑性构成了生理记忆，因为它是联想的、高度特定的、有辨别力的、发展迅速的，并被无限期地保留。这项研究探讨了在清醒的豚鼠中，基底核(NB)的激活是否可以诱导RF可塑性，如果可以，这种可塑性是否可以保持24小时。受试者接受了40次单一频率的试验，并在音调偏移时对NB进行电刺激。随后，当受试者用乌拉坦麻醉时，通过记录刺激是否产生皮质去同步化来评估NB刺激的生理效果。在NB刺激有效的受试者中确实发展了RF可塑性，并且这种可塑性保持了24小时。因此，在正常学习期间激活NB可能足以在听觉皮质中诱导持久的生理记忆。(心理信息数据库记录(C)2016 APA，版权所有)
Learning induces neuronal receptive field (RF) plasticity in primary auditory cortex. This plasticity constitutes physiological memory as it is associative, highly specific, discriminative, develops rapidly, and is retained indefinitely. This study examined whether pairing a tone with activation of the nucleus basalis (NB) could induce RF plasticity in the waking guinea pig and, if so, whether it could be retained for 24 hrs. Subjects received 40 trials of a single frequency paired with electrical stimulation of the NB at tone offset. The physiological effectiveness of NB stimulation was assessed later while subjects were anesthetized with urethane by noting whether stimulation produced cortical desynchronization. Subjects in which NB stimulation was effective did develop RF plasticity and this was retained for 24 hrs. Thus, activation of the NB during normal learning may be sufficient to induce enduring physiological memory in auditory cortex.(PsycINFO Database Record (c) 2016 APA, all rights reserved)