Variants of COL3A1 Are Associated with the Risk of Stroke Recurrence and Prognosis in the Chinese Population: a Prospective Study
Variants of COL3A1 Are Associated with the Risk of Stroke Recurrence and Prognosis in the Chinese Population: a Prospective Study
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COL3A1 变异与中国人群卒中复发风险和预后相关：一项前瞻性研究
DOI：
10.1007/s12031-014-0283-x
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发表时间：
2014-06-01
影响因子：
3.1
通讯作者：
Chen, Jingzhou
中科院分区：
文献类型：
--
作者：
Lv, Wenfei;Lin, Yahui;Chen, Jingzhou
III型胶原蛋白在激活血小板、形成血栓和维持动脉机械性能方面发挥着重要作用。本研究旨在验证COL 3A 1（编码III型胶原蛋白的基因）的遗传变异有助于卒中复发和预后的假设。我们研究了COL 3A 1基因的三个变异体（rs 2138533、rs 11887092和rs 1800255）与1,544例患有三种亚型卒中的患者的卒中复发和预后的关系：腔隙性梗死（n = 442）、动脉粥样硬化血栓性梗死（n = 670）和出血（n = 432）。Kaplan-Meier分析和考克斯回归模型评估这些关联。随访4.5年。COL 3A 1基因编码区rs 1800255的A等位基因与腔隙性脑梗死患者卒中复发风险降低显著相关（校正的风险比[HR] 0.58，95%置信区间[CI] 0.36-0.93，P = 0.024），但动脉粥样硬化血栓形成患者的全因死亡风险增加（校正HR 1.43，95% CI 1.01-2.00，P = 0.044）。rs 2138533的TT基因型显示腔隙性脑梗死患者因心血管疾病或卒中导致的死亡风险显著增加（校正HR 2.98，95% CI 1.27-6.98，P = 0.012），但脑出血患者的全因死亡率风险降低（校正HR 0.34，95% CI 0.12-0.93，P = 0.036）。rs 11887092的G等位基因增加了动脉粥样硬化血栓性卒中患者卒中复发的风险（校正HR 1.59，95%CI 1.04-2.44，P = 0.035）。总之，COL 3A 1的变异体可能在确定卒中后复发风险和预后方面发挥重要作用。
Type III collagen plays an important role in activating platelets, forming thrombus, and maintaining the mechanical properties of arteries. This study aimed to test the hypothesis that genetic variants of COL3A1 (gene encoding type III collagen) contribute to recurrence and prognosis of stroke. We investigated the associations of three variants (rs2138533, rs11887092, and rs1800255) in the COL3A1 gene with stroke recurrence and prognosis in 1,544 patients with three subtypes of stroke: lacunar infarction (n = 442), atherothrombotic infarction (n = 670), and hemorrhage (n = 432). These associations were evaluated by Kaplan-Meier analysis and Cox regression models. Patients were followed up for 4.5 years. The A allele of rs1800255 in the COL3A1 gene coding region was significantly associated with a reduced risk of stroke recurrence in patients with lacunar infarction (adjusted hazard ratio [HR] 0.58, 95 % confidence interval [CI] 0.36-0.93, P = 0.024), but there was an increased risk of all-cause mortality of atherothrombotic patients (adjusted HR 1.43, 95 % CI 1.01-2.00, P = 0.044). The TT genotype of rs2138533 showed a significantly increased risk of death caused by cardiovascular disease or stroke in lacunar infarct patients (adjusted HR 2.98, 95 % CI 1.27-6.98, P = 0.012), but there was a reduced risk of all-cause mortality for patients with intracerebral hemorrhage (adjusted HR 0.34, 95 % CI 0.12-0.93, P = 0.036). The G allele of rs11887092 increased the risk of stroke recurrence in patients with atherothrombotic stroke (adjusted HR 1.59, 95 % CI 1.04-2.44, P = 0.035). In conclusion, variants of COL3A1 might play a vital role in determining the risk of recurrence and prognosis after stroke.