The animal trypanosomiases and their chemotherapy: a review.
The animal trypanosomiases and their chemotherapy: a review.
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DOI：
10.1017/s0031182016001268
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发表时间：
2016-12
期刊：
影响因子：
2.4
通讯作者：
Barrett MP
中科院分区：
文献类型：
--
作者：
Giordani F;Morrison LJ;Rowan TG;DE Koning HP;Barrett MP
几个世纪以来，影响牲畜的病原动物锥虫一直是非洲农业发展的主要制约因素，其负面经济影响在南美洲和亚洲日益严重。化疗和化学预防是控制的主要手段。然而，几十年来，对新的锥虫杀虫剂的研究仍然不足，导致由于抗药性寄生虫的出现，现有的少数化合物正在失去效力。在这篇综述中，我们提供了一个全面的概述，目前可用于治疗和预防的动物锥虫病的选择，特别关注的问题的阻力。还介绍了围绕主要经济重要动物锥虫物种及其引起的疾病的关键问题。随着新的投资可用于开发控制动物锥虫病的改进工具，我们强调，应努力更好地了解相关寄生虫物种和菌株的生物学，以确定新的药物靶点并询问耐药机制。
Pathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative economic impact is increasing in South America and Asia. Chemotherapy and chemoprophylaxis represent the main means of control. However, research into new trypanocides has remained inadequate for decades, leading to a situation where the few compounds available are losing efficacy due to the emergence of drug-resistant parasites. In this review, we provide a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance. The key issues surrounding the main economically important animal trypanosome species and the diseases they cause are also presented. As new investment becomes available to develop improved tools to control the animal trypanosomiases, we stress that efforts should be directed towards a better understanding of the biology of the relevant parasite species and strains, to identify new drug targets and interrogate resistance mechanisms.