Hippocampus, time, and memory--a retrospective analysis.
Hippocampus, time, and memory--a retrospective analysis.
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DOI：
10.1037/a0034201
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发表时间：
2013-10
影响因子：
1.9
通讯作者：
Matell MS
中科院分区：
文献类型：
--
作者：
Meck WH;Church RM;Matell MS
1984年，有大量证据表明海马体对于空间学习很重要，并且一些证据表明它还参与持续时间歧视。然而，《海马、时间和记忆》一文是第一篇分离出海马损伤对时间处理特定阶段的影响的文章。在这篇综述中，为了庆祝行为神经科学诞生 30 周年，我们回顾了导致本文产生持久影响的因素。主要结果是，穹窿伞损伤（a）干扰了在时间工作记忆中保留信息的能力，（b）扭曲了时间参考记忆的内容，但（c）它并没有降低对信号持续时间的敏感性。这是第一个用完善的行为理论（标量计时理论）解释结果的损伤实验。它导致许多研究人员对海马体在时间处理中的作用进行了广泛的研究。最重要的是开发具有合理神经机制的计算模型（例如间隔计时的纹状体节拍频率模型），使用多种计时行为测量方法，以及使用前额叶-纹状体-海马回路中神经元的整体记录对计时和时间记忆的神经机制进行实证研究。
In 1984, there was considerable evidence that the hippocampus was important for spatial learning and some evidence that it was also involved in duration discrimination. The article Hippocampus, Time, and Memory, however, was the first to isolate the effects of hippocampal damage on specific stages of temporal processing. In this review, to celebrate the 30th anniversary of Behavioral Neuroscience, we look back on factors that contributed to the long-lasting influence of this article. The major results were that a fimbria-fornix lesion (a) interferes with the ability to retain information in temporal working memory and (b) distorts the content of temporal reference memory, but (c) it did not decrease sensitivity to signal duration. This was the first lesion experiment in which the results were interpreted by a well-developed theory of behavior (scalar timing theory). It has led to extensive research on the role of the hippocampus in temporal processing by many investigators. The most important ones are the development of computational models with plausible neural mechanisms (such as the Striatal Beat-Frequency model of interval timing), the use of multiple behavioral measures of timing, and empirical research on the neural mechanisms of timing and temporal memory using ensemble recording of neurons in prefrontal-striatal-hippocampal circuits.