Early grade repetition and inattention associated with neurofibromatosis type 1.
Early grade repetition and inattention associated with neurofibromatosis type 1.
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DOI：
10.1177/1087054707299398
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发表时间：
2007-09-01
影响因子：
3
通讯作者：
Munnich, Arnold
中科院分区：
文献类型：
--
作者：
Coude, Francois X;Mignot, Claire;Munnich, Arnold
目的：分析1型神经纤维瘤病(NF1)患儿分级重复和注意力不集中的发生情况。方法：310例NF1患儿为研究对象，242例为对照组。记录每个参与者在小学、初中和高中期间的年级重复次数，并根据Barkley的ADHD临床家长访谈表计算注意力不集中分数。结果：53%的NF1患者与25%的对照组相比，年级重复增加，P2(1)=27.41，p<0.0001；67%的NF1患者与14%的对照组发现注意力不集中，2(1)=27.41，p&t；0.0001。重复主要影响幼儿园和一年级的水平，在NF1患者中，注意力不集中得分与年级重复发生率显著相关(R2=.7429，p<；.0004)。结论：年级重复是NF1的常见并发症，与该疾病患者的注意力不集中有关。
OBJECTIVE: The authors analyze the occurrence of grade repetition and inattention in children diagnosed with neurofibromatosis type 1 (NF1).METHOD: The participant group consisted of 310 patients with NF1 and a control group of 242 individuals. The number of grade repetitions for each participant during his or her time in elementary, middle, and high school was noted and the inattention score was calculated from the Barkley's ADHD Clinic Parent Interview form.RESULTS: Fifty-three percent of NF1 patients versus 25% of the controls had increased grade repetition, P2 (1) = 27.41, p < .0001, and 67% of NF1 patients versus 14% of controls were found to be inattentive, 2 (1) = 27.41, p < .0001. Repetition mainly affected kindergarten and first-grade levels and the inattention score significantly correlated with grade repetition prevalence in NF1 patients (r2 = .7429, p < .0004).CONCLUSION: Grade repetition is a frequent complication in NF1 and correlates with inattention in individuals with this disease.