Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor.
Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor.
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由于异位胰岛细胞肿瘤分泌生长激素而导致肢端肥大症。
DOI：
10.1056/nejm198501033120103
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Frohman,LA
中科院分区：
文献类型：
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作者：
Melmed,S;Ezrin,C;Kovacs,K;Goodman,RS;Frohman,LA
肢端肥大症的临床特征直接或间接由生长激素的持续分泌过多引起。123生长激素细胞腺瘤，或在极少数情况下的增生，构成了引起肢端肥大症的病理性垂体病变。4，5在极少数情况下，肢端肥大症可能是由蝶窦或咽旁窦的异位生长激素细胞腺瘤引起的。4，5最近的注意力集中在类癌6和胰岛细胞肿瘤7引起肢端肥大症的生长激素释放因子的阐述上。事实上，人类生长激素释放因子的结构首先是从两种胰腺肿瘤提取物中阐明的，这两种提取物在体外和体内都能刺激生长激素的释放。
THE clinical features of acromegaly result directly or indirectly from sustained hypersecretion of growth hormone.123Somatotroph-cell adenomas, or in rare cases hyperplasia, constitute the pathologic pituitary lesions causing acromegaly.4,5Also in rare cases, acromegaly may be caused by ectopic somatotroph-cell adenomas in the sphenoid or parapharyngeal sinuses.4,5Attention has recently been focused on the elaboration of growth hormone–releasing factors by carcinoid6and pancreatic islet-cell tumors7causing acromegaly. The structure of human growth hormone–releasing factor was, in fact, first elucidated from two such pancreatic tumor extracts, which were shown to stimulate growth hormone release both in vitro and in vivo.8,9Ectopic . . .