Planned neck dissection following chemoradiotherapy for advanced head and neck cancer: Is it necessary for all?
Planned neck dissection following chemoradiotherapy for advanced head and neck cancer: Is it necessary for all?
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晚期头颈癌放化疗后计划进行颈清扫术：对所有人都有必要吗？
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
W. Wei
中科院分区：
文献类型：
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作者：
P. Pellitteri;A. Ferlito;A. Rinaldo;J. Shah;R. Weber;J. Lowry;J. Medina;C. Gourin;K. Robbins;C. Suárez;A. Shaha;E. Genden;C. R. Leemans;J. Lefebvre;Luiz P. Kowalski;W. Wei
由于缺乏大规模随机试验来评估新辅助放化疗后颈清扫术与受累颈部观察的比较，因此需要收集数据来支持或最终反驳计划的治疗后颈清扫术的作用。对放化疗完全缓解的广泛性（N2 或 N3）颈部疾病患者中，很大一部分可能存在残留的隐匿性转移，识别这部分患者仍然是一个临床挑战。由于当隐匿性淋巴结病出现临床表现时，手术挽救率会大大降低，因此提倡计划性治疗后颈清扫术，但可能并非对所有患者都有必要。正电子发射断层扫描放化疗 (PET-CT) 在这种情况下的作用尚未得到证实，但有希望能够识别哪些患者在放化疗后颈部可能存在残留疾病。将尚未鉴定的分子肿瘤标志物与 PET-CT 相结合，最终可能被证明可以有效地识别最能从治疗后颈清扫术中获益的患者。成像结果和病理淋巴结状态的相关性对于确定准确性非常重要，因此，这种成像方式对于预测是否存在残留疾病的价值也很重要。 © 2005 Wiley periodicals, Inc. Head Neck 27：XXX–XXX，2005 年
In the absence of large‐scale randomized trials evaluating dissection versus observation of the involved neck after neoadjuvant chemoradiotherapy, there is a need to collect data that will either support or ultimately refute a role for planned posttreatment neck dissection. A significant percentage of patients with extensive (N2 or N3) neck disease who demonstrate a complete response to chemoradiation therapy may harbor residual occult metastases, and identification of this subset of patients remains a clinical challenge. Because surgical salvage rates are greatly diminished when occult nodal disease becomes clinically manifest, planned posttreatment neck dissection is advocated but may not be necessary in all patients. The role of positron emission tomography chemoradiotherapy (PET‐CT) in this scenario remains unproven but holds promise in being able to identify which patients may be harboring residual disease in the neck after chemoradiotherapy. The implementation of as yet unidentified molecular tumor markers in combination with PET‐CT may ultimately prove to be effective in identifying patients who will best benefit from posttherapy neck dissection. Correlation of imaging results and pathologic node status will be important in determining the accuracy and, therefore, the value of this imaging modality for predicting the presence or absence of residual disease. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005
作为保留喉方法的一部分，对临床阳性颈部进行管理。
DOI：
10.1016/0360-3016(93)90489-i
发表时间：
1993
期刊：
International journal of radiation oncology, biology, physics
影响因子：
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作者：
Armstrong,J;Pfister,D;Strong,E;Heimann,R;Kraus,D;Polishook,A;Zelefsky,M;Bosl,G;Shah,J;Spiro,R
通讯作者：
Spiro,R
影响因子：
45.3
作者：
Adelstein, DJ;Li, Y;Forastiere, AA
通讯作者：
Forastiere, AA
放疗联合化疗“增强”晚期头颈部鳞状细胞癌的 I/II 期试验：毒性和反应。
DOI：
10.1200/jco.1999.17.8.2390
发表时间：
1999
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Garden,AS;Glisson,BS;Ang,KK;Morrison,WH;Lippman,SM;Byers,RM;Geara,F;Clayman,GL;Shin,DM;Callender,DL;Khuri,FR;Goepfert,H;Hong,WK;Peters,LJ
通讯作者：
Peters,LJ