Endurance training attenuates the increase in peripheral chemoreflex sensitivity with intermittent hypoxia.
Endurance training attenuates the increase in peripheral chemoreflex sensitivity with intermittent hypoxia.
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耐力训练减弱了间歇性缺氧时外周化学反射敏感性的增加。
DOI：
10.1152/ajpregu.00105.2016
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Leuenberger,UrsA
中科院分区：
文献类型：
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作者：
Miller,AmandaJ;Sauder,CharityL;Cauffman,AimeeE;Blaha,CherylA;Leuenberger,UrsA
心力衰竭和睡眠呼吸暂停患者有更大的化学反射敏感性，可能是由于间歇性缺氧（IH），这是死亡率的预测因素。我们假设耐力训练可以减弱IH对健康人外周化学反射敏感性的影响。15名健康青年（女性9名，年龄26±1岁）参与研究。在两次访问之间，11名受试者接受了8周的耐力训练，包括以80%预测最大心率/周跑步4次和间歇训练，而4名对照受试者没有改变活动。化疗反射敏感性（连续氧饱和度下通气反应的斜率）、血压、心率和肌肉交感神经活动（MSNA）在IH前后30分钟进行评估。耐力训练降低静息收缩压（119±3至113±3 mmHg， P= 0.027）和心率（67±3至61±2次/分钟，P= 0.004），但未改变静息呼吸参数（P < 0.05）。耐力训练减弱了ih诱导的化学反射敏感性的增加（训练前：Δ 0.045±0.026 vs.训练后：Δ−0.028±0.040 l·min−1·% o2去饱和度−1；P= 0.045）。此外，训练前IH升高了平均血压和MSNA爆发率（P< 0.05），但训练后IH没有改变这些指标（P< 0.05）。在两次访问中，对照组的所有测量结果相似（P < 0.05）。耐力训练减弱了对IH的化学反射敏感性，这可能部分解释了运动训练对心血管疾病患者的有益作用。
Patients with heart failure and sleep apnea have greater chemoreflex sensitivity, presumably due to intermittent hypoxia (IH), and this is predictive of mortality. We hypothesized that endurance training would attenuate the effect of IH on peripheral chemoreflex sensitivity in healthy humans. Fifteen young healthy subjects (9 female, 26 ± 1 yr) participated. Between visits, 11 subjects underwent 8 wk of endurance training that included running four times/wk at 80% predicted maximum heart rate and interval training, and four control subjects did not change activity. Chemoreflex sensitivity (the slope of ventilation responses to serial oxygen desaturations), blood pressure, heart rate, and muscle sympathetic nerve activity (MSNA) were assessed before and after 30 min of IH. Endurance training decreased resting systolic blood pressure (119 ± 3 to 113 ± 3 mmHg;P= 0.027) and heart rate (67 ± 3 to 61 ± 2 beats/min;P= 0.004) but did not alter respiratory parameters at rest (P> 0.2). Endurance training attenuated the IH-induced increase in chemoreflex sensitivity (pretraining: Δ 0.045 ± 0.026 vs. posttraining: Δ −0.028 ± 0.040 l·min−1·% O2desaturation−1;P= 0.045). Furthermore, IH increased mean blood pressure and MSNA burst rate before training (P< 0.05), but IH did not alter these measures after training (P> 0.2). All measurements were similar in the control subjects at both visits (P> 0.05). Endurance training attenuates chemoreflex sensitization to IH, which may partially explain the beneficial effects of exercise training in patients with cardiovascular disease.