Localization of the extracellular matrix protein SC1 coincides with synaptogenesis during rat postnatal development
Localization of the extracellular matrix protein SC1 coincides with synaptogenesis during rat postnatal development
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DOI：
10.1007/s11064-008-9606-z
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发表时间：
2008-09-01
影响因子：
4.4
通讯作者：
Brown, Ian R.
中科院分区：
文献类型：
--
作者：
Lively, Starlee;Brown, Ian R.
SC1是一种细胞外基质蛋白，属于基质细胞分子SPARC家族。这种抗黏附蛋白定位于成年大鼠大脑中的突触，并被认为调节突触的形状。在这项研究中，SC1的水平在出生后10-20天被检测到升高，并在出生后15天达到高峰，这是一个强烈的突触发生时期。在此期间，观察到SC1与突触标记突触素在小脑和大脑皮层突触丰富区域的共存增加。这些结果表明，在大鼠出生后发育过程中，SC1的定位模式与突触发生相吻合。
SC1 is an extracellular matrix protein that belongs to the SPARC family of matricellular molecules. This anti-adhesive protein localizes to synapses in the adult rat brain and has been postulated to modulate synapse shape. In this study, increased levels of SC1 were detected from postnatal days 10-20, with a peak at postnatal day 15, a period of intense synaptogenesis. During this time, increased colocalization of SC1 with the synaptic marker synaptophysin was observed in synapse-rich regions of the cerebellum and the cerebral cortex. These findings indicate that the pattern of SC1 localization coincided with synaptogenesis during rat postnatal development.