Prepulse inhibition and latent inhibition: The role of dopamine in the medial prefrontal cortex
Prepulse inhibition and latent inhibition: The role of dopamine in the medial prefrontal cortex
复制标题
DOI：
10.1016/0306-4522(96)00307-7
复制
发表时间：
1996-11-01
期刊：
影响因子：
3.3
通讯作者：
Cools, AR
中科院分区：
文献类型：
--
作者：
Ellenbroek, BA;Budde, S;Cools, AR
前额皮质经常与精神分裂症的病理生理学有关。已知精神分裂症患者患有某些信息处理缺陷，这些缺陷可以在前脉冲抑制和潜在抑制范例中检测到。本研究旨在研究内侧前额叶皮层多巴胺受体在前脉冲抑制和潜伏抑制中的作用。结果表明，将多巴胺 D-1 样受体家族选择性拮抗剂 SCH 39166 局部应用到内侧前额叶皮层，可剂量依赖性地降低前脉冲抑制。同样，多巴胺 D-2 样受体家族的选择性拮抗剂舒必利注射到内侧前额皮质后，会剂量依赖性地降低前脉冲抑制。然而，这些拮抗剂都不影响用条件味觉厌恶范式测量的潜在抑制。这些数据进一步表明潜在抑制和前脉冲抑制的神经元底物明显不同。由于前额叶皮层与皮质下多巴胺密切相关，因此讨论了皮质下多巴胺能末端区域在前脉冲抑制和潜在抑制中可能的差异参与。版权所有 (C) 1996 IBRO。
The prefrontal cortex has often been implicated in the pathophysiology of schizophrenia. Schizophrenic patients are known to suffer from certain information processing deficits, which can be detected, among others, in the prepulse inhibition and the latent inhibition paradigm. The present study was designed to investigate the role of dopamine receptors in the medial prefrontal cortex in prepulse inhibition and latent inhibition. The results show that the local application of the selective antagonist of the dopamine D-1-like receptor family, SCH 39166, into the medial prefrontal cortex dose-dependently reduced prepulse inhibition. Likewise, the selective antagonist of the dopamine D-2-like receptor family, sulpiride, injected into the medial prefrontal cortex dose-dependently reduced prepulse inhibition. Neither of these antagonists, however, influenced latent inhibition as measured with the conditioned taste aversion paradigm. These data further indicate that the neuronal substrates of latent inhibition and prepulse inhibition are clearly different.Since the prefrontal cortex is intimately related to subcortical dopamine, the possible differential involvement of subcortical dopaminergic terminal fields in prepulse inhibition and latent inhibition is discussed. Copyright (C) 1996 IBRO.