Rewarding properties of testosterone in intact male mice: A pilot study
Rewarding properties of testosterone in intact male mice: A pilot study
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DOI：
10.1016/s0091-3057(99)00189-6
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发表时间：
2000-02-01
影响因子：
3.6
通讯作者：
Gonzalez-Bono, E
中科院分区：
文献类型：
--
作者：
Arnedo, MT;Salvador, A;Gonzalez-Bono, E
本研究利用条件位置偏好（CPP）技术研究了4-雄烯酮-17 - β -醇-3- 1睾酮在完整雄性小鼠中的奖励特性。在实验1中，研究了0.8和1.2 mg/kg睾酮的药代动力学，以确定最合适的时间间隔来测试行为。此外，记录运动活动以控制可能对CPP的干扰作用。最大睾酮浓度记录在给药45分钟，没有发现对活动的影响。在实验2中，三组雄性of -1小鼠接受四组最不喜欢的睾酮室（0.8、1或1.2 mg/kg， SC），持续30分钟。隔天将首选隔间与车辆配对30分钟。对照组在两个车厢都接受了车辆。在药物配对室中花费的时间在两组之间没有显着差异。然而，当结合药物配对室的颜色进行单独分析时，仅在睾酮/黑色室配对的动物中观察到CPP。这些结果表明，睾酮治疗的有益特性可以在雄性小鼠中观察到；这些影响可能依赖于作为条件刺激的环境线索。(C) 2000 Elsevier Science Inc.；
The present study examined the rewarding properties of 4-androsten-17 beta-ol-3-one testosterone in intact male mice using the conditioned place preference (CPP) technique. In Experiment 1, the pharmacokinetics of 0.8 and 1.2 mg/kg of testosterone were studied to determine the most appropriate temporal interval to test behavior. Additionally, the locomotor activity was recorded to control a possible interfering effect on CPP. The maximum testosterone concentration was registered at 45 min of administration, and no effects on activity were found. In Experiment 2, three groups of male OF-1 mice received four pairings of the least-preferred compartment with testosterone (0.8, 1, or 1.2 mg/kg, SC) for 30 min. On alternate days the preferred compartment was paired with vehicle for 30 min. The control group received vehicle in both compartments. No significant differences between groups were found in the time spent in the drug-paired compartment. However, when separate analyses were performed in conjunction with the color of the drug-paired compartment, CPP was observed only in animals pairing testosterone/black compartment. These results suggest that rewarding properties of testosterone treatment can be observed in male mice; these effects probably being dependent on the environmental cues used as conditioned stimuli. (C) 2000 Elsevier Science Inc.